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EGF — GYS2

Text-mined interactions from Literome

Shaw et al., FEBS Lett 1999 (MAP Kinase Signaling System) : Epidermal growth factor (EGF) , insulin-like growth factor 1 (IGF1) and phorbol myristate acetate ( PMA ) induce the inhibition of glycogen synthase kinase 3 ( GSK3 ) by stimulating the phosphorylation of an N-terminal serine
Robinson et al., J Biol Chem 1993 : The role of mitogen activated protein ( MAP ) kinase in the regulation of glucose metabolism has been investigated by comparing the effects of insulin and epidermal growth factor (EGF) on MAP kinase activation, glucose transport, and glycogen synthase in 3T3-L1 adipocytes
Azpiazu et al., J Biol Chem 1996 : Epidermal growth factor (EGF) was more effective than insulin in increasing MAP kinase and Rsk activity, but in contrast to insulin, EGF did not affect glycogen synthase activity
Van Epps-Fung et al., Diabetes 1996 : EGF induced incorporation into glycogen at roughly 60 % of the level of insulin ( 4.53 +/- 0.57-fold for insulin vs. 2.76 +/- 0.25-fold for EGF ) ; this corresponded with similarly lower levels of glycogen synthase activation by EGF relative to insulin stimulation
Yasui et al., Eur J Pharmacol 1996 : We investigated the involvement of 90-kDa S6 kinase in the control of insulin- or epidermal growth factor (EGF) stimulated glycogen synthase activation using newly synthesized compounds which selectively inhibit 90-kDa S6 kinase ... HH-5709, however, failed to affect the glycogen synthase activation by either insulin or EGF ... These findings suggest that 90-kDa S6 kinase is unrelated or insufficient to mediate activation of glycogen synthase and that unidentified pathway ( s ) sensitive to H-7 or HA-1077 would be involved in the activation of glycogen synthase by insulin or EGF in 3Y1 fibroblasts
Peak et al., Diabetologia 1998 : Both insulin and EGF activated extracellular regulated kinase 2 (ERK-2), p70rsk and protein kinase B (PKB) and inactivated glycogen synthase kinase-3 ( GSK-3 )