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EGF — STAT5A

Text-mined interactions from Literome

Olayioye et al., J Biol Chem 1999 : However, an intact SH2 domain was necessary for EGF induced Stat5a phosphorylation
Rebsamen et al., J Mol Cell Cardiol 2000 (Cardiomegaly) : EGF did not activate Stat1 and Stat3, but did induce a rapid and transient activation of Stat5 , which corresponded mainly to Stat5b DNA binding ... The results further show that EGF activates Stat5 , that this response requires p38 MAPK stimulation, and it is negatively modulated by p42/44 MAPK
Nevalainen et al., Mol Endocrinol 2002 : First, administration of PRL, but not GH or epidermal growth factor , uniformly enhanced basal activation of Stat5 in luminal mammary epithelial cells
Tonko-Geymayer et al., Mol Endocrinol 2002 : Our data indicate that in the mammary gland CIS and SOCS3 are involved in regulating STAT5 signaling at three different instances : 1 ) SOCS3 serves as a mediator of the inhibitory EGF effect on PRL induced STAT5 activation ; 2 ) CIS and SOCS3 play a role as negative feedback inhibitors of PRL action ; 3 ) Inhibition of CIS and SOCS3 expression by glucocorticoids contributes to the positive effect of glucocorticoids on PRL induced STAT5 activation
Sato et al., Genes Cells 2003 : Phosphorylation of Stat 3/5 in response to p52shc expression, EGF or H2O2 could also be inhibited by introduction into cells of phospho-Tyr 845-specific antibody or by expression of dominant negative version of c-Src
Simard et al., Endocr Rev 2005 : It was shown that epidermal growth factor (EGF) requires intact STAT5 ; on the other hand IL-4 induces HSD3B1 gene expression, along with IL-13, through STAT 6 activation
Itoh et al., Oncogene 2006 (Urinary Bladder Neoplasms) : We report that STAT3, but not STAT1 and STAT5 , becomes phosphorylated in response to epidermal growth factor (EGF) and achieves maximal induction of collagenase-1 ( MMP-1 ) transcription by interacting with c-JUN
Olsen et al., Exp Cell Res 2006 (MAP Kinase Signaling System) : In HC11 cells, EGF inhibited TZD induced STAT5A-reporter activity suggesting that our previously reported EGF mediated suppression of STAT5A expression is mediated in all or partly through inhibition of PPARgamma activity
Mirmohammadsadegh et al., J Invest Dermatol 2006 (Melanoma) : The investigation of the underlying mechanism revealed specific STAT5 activation by recombinant human epidermal growth factor ( rEGF )
Lopez-Perez et al., Int J Biochem Cell Biol 2006 (Breast Neoplasms) : Our results demonstrate that stimulation of MCF7 cells with epidermal growth factor (EGF) promoted an increase in the phosphorylation of STAT5 at Tyr-694, as revealed by site-specific antibodies that recognized the phosphorylated state of this residue ... In addition, EGF stimulated STAT5 nuclear translocation and an increased in STAT5 DNA binding activity
Quesnelle et al., J Cell Biochem 2007 (Neoplasms) : EGFR likely activates STAT in a manner distinctive from other mechanisms of STAT activation ; STAT5 can be phosphorylated in an EGF dependent manner at unique sites, conferring novel functions
Hung et al., Nucleic Acids Res 2008 (Chromosomal Instability) : A co-immunoprecipitation assay further demonstrated that EGF induces nuclear interaction between EGFR and STAT5
Fox et al., Steroids 2009 : STAT5 is phosphorylated in the cytoplasm at an activating tyrosine in response to E2 or EGF , and then is translocated to the nucleus to stimulate target gene transcription ... STAT5 activation by E2 in breast cancer cells requires c-Src and EGF receptor, and inhibition of c-Src or EGFR, or knockdown of STAT5, prevents E2 stimulation of several genes and breast cancer cell proliferation
González et al., J Endocrinol 2010 : Consequently, EGF induced phosphorylation of EGFR, AKT, ERK1/2, STAT3, and STAT5 was significantly decreased in these mice ... However, EGF stimulation caused similar levels of EGFR, AKT, and ERK1/2 phosphorylation in normal and transgenic mice, while EGF induction of STAT3 and STAT5 phosphorylation was inhibited in the transgenic mice
Yuan et al., J Biol Chem 2010 (Breast Neoplasms...) : Furthermore, PTPN9 WT expression specifically impairs EGF induced STAT3 and STAT5 activation, and inhibits the cell growth in soft agar
Cao et al., Zhongguo Fei Ai Za Zhi 2013 (Adenocarcinoma...) : The aim fo this study is to investigate whether the epidermal growth factor (EGF) can stimulate the signal transducers and activators of transcription 5 ( STAT5 ) as well as to discover the effects of the STAT5 signaling pathway on the COX-2 in human lung adenocarcinoma A549 cells ... EGF stimulation significantly increased the level of the p-STAT5 protein and induces the shuttling of p-STAT5 from the cytoplasm into the nucleus
Nakamura et al., J Biol Chem 1996 : EGF stimulation of the transfectants induced dose dependent tyrosine phosphorylation of the EGFR/Jak2 chimera and Stat5 , which correlated with the EGF dose dependence of cell proliferation
Wakao et al., Biochem Biophys Res Commun 1997 : Like EPO, EGF equally activated Stat5 and induced hemoglobin ... Activation of Stat5 and hemoglobin expression by EGF were markedly impaired in cells expressing the tyrosine mutated chimeric receptors