Sheng et al., J Biol Chem 2000
:
Transforming growth factor-beta1 enhances Ha-ras induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
Van Putten V et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Stable expression of H-Ras increased expression of cPLA(2) and COX-2 protein
Lee et al., Ann N Y Acad Sci 2004
:
H-ras induced COX-2 expression in WB-F344 rat liver epithelial cells ( WB cells ) ... In conclusion, CAPE may exert cancer chemopreventive effects through the inhibition of COX-2 expression and the restoration of disrupted GJIC induced by H-ras , possibly by targeting NF-kappaB
Lao et al., Carcinogenesis 2012
(Cell Transformation, Neoplastic...) :
Transformed COX-2+/+ and COX-2-/- keratinocytes expressed similar levels of H-ras , epidermal growth factor receptor and phospho-extracellular signal regulated kinase1/2 in vitro ; and COX-2-deficiency did not reduce uninfected or v-H-ras infected keratinocyte replication