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CSF2 — JAK1
Text-mined interactions from Literome
Liva et al., Glia 1999
:
We show here that primary microglia and a microglia cell line, BV-2, have a
Jak/STAT expression pattern and
GM-CSF inducibility similar to that of monocytes and macrophages
Choi et al., Neurosci Lett 2007
:
However,
Janus kinase 2 (JAK2) was
activated only in A172 cells but not in SK-N- ( BE ) 2 cells by
GM-CSF
Kasper et al., J Interferon Cytokine Res 2007
:
However,
GM-CSF induced downregulation of Tyk2 and
Jak1 tyrosine phosphorylation as well as Tyk2 protein levels likely contributed to the reduced Stat1 tyrosine phosphorylation
van der Plas et al., Leukemia 1996
(Burkitt Lymphoma...) :
Activation of the chimeric
G-CSF-R/IL-7R alpha with G-CSF resulted in a full proliferative response and
induced the phosphorylation of
JAK1 but not JAK2
Noda et al., Int J Cancer 1999
(Carcinoma, Squamous Cell...) :
Furthermore, stimulation of IMC-2 cells with
rG-CSF induced rapid
activation of tyrosine phosphorylated
JAK1 , suggesting that the G-CSF signal may be transduced into the cells through G-CSFR