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AIP — CASP5
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Cao et al., J Neurosci 2004
(Brain Ischemia...) :
AAV mediated overexpression of
AIP in primary cortical- hippocampal neurons markedly
reduced cell death and
caspase-3 activation triggered by protein kinase C inhibition, DNA damage, or oxygen- glucose deprivation
Goebel et al., Brain Res 2009
(Necrosis) :
Results confirmed that
AIP fully
attenuates caspase-3 activation for at least 8 h following NMDA insult and also significantly improves retinal ganglion cell survival