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BCL10 — IGF1
Text-mined interactions from Literome
Leverrier et al., Cell Death Differ 1999
:
Role of PI3-kinase in
Bcl-X induction and apoptosis inhibition
mediated by IL-3 or
IGF-1 in Baf-3 cells
Fornoni et al., Am J Pathol 2001
:
We investigated whether
Bcl-xL and Fas/Fas-ligand were regulated by CsA in cultured podocytes and whether CsA induced apoptosis was
prevented by HGF or
IGF-I ... HGF, but not
IGF-I , prevented apoptosis and
restored Bcl-xL levels
Yamamura et al., Am J Physiol Heart Circ Physiol 2001
(Myocardial Reperfusion Injury) :
IGF-I differentially
regulates Bcl-xL and Bax and confers myocardial protection in the rat heart ... These results suggest that
IGF-1 differentially
regulates Bcl-xL and Bax in heart mitochondria, which may be causally related to myocardial protection against ischemia-reperfusion injury
Nakao et al., J Thorac Cardiovasc Surg 2001
(Disease Models, Animal...) :
Immunohistochemical studies revealed that
insulin-like growth factor 1 increased expression of the antiapoptotic
Bcl-xL protein and inhibited expression of the proapoptotic Bax protein in motor neuron cells 24 and 48 hours after the operation
Hilmi et al., J Invest Dermatol 2008
(Melanoma) :
Accordingly,
IGF1 increases the mRNA levels and protein expression of antiapoptotic members of the BCL2 family -- BCL2 and
BCL-X ( L ) -- and that of the inhibitor of apoptosis protein, survivin ... Accordingly,
IGF1 increases the mRNA levels and protein expression of antiapoptotic members of the BCL2 family -- BCL2 and
BCL-X ( L ) -- and that of the inhibitor of apoptosis protein, survivin
Singh et al., Growth Factors 2008
(Breast Neoplasms) :
Furthermore,
IGF-II differentially
regulated the intracellular translocation of Bcl-2 and
Bcl-X ( L ), a critical process in breast cancer progression to hormone-independence
Singleton et al., J Biol Chem 1996
:
Finally, increased neuronal
IGF-IR expression
enhances the negative death regulator
Bcl-xL
Suzuki et al., FEBS Lett 1998
:
It was also found that R-Ras and
IGF-1 cooperatively
induced Bcl-xL expression and inhibited caspase-3 activation