Gene interactions and pathways from curated databases and text-mining

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FOS — SOCS3

Text-mined interactions from Literome

Miao et al., Mol Cell Neurosci 2008 (Neuroblastoma) : Mutant SOCS3 increased AP-1 ( activator protein ) transcriptional activity and JNK ( c-Jun N-terminal kinase ) activity and SOCS3 bound to the scaffolding protein, JNK interacting protein-1 : these observations provide a plausible explanation for the enhancement by mutant SOCS3 of the actions of CNTF
Wiejak et al., Mol Pharmacol 2012 : In addition AP-1 , pSTAT, and SP1/SP3 binding sites were required for ERK dependent, PMA stimulated SOCS-3 gene activation
Wiejak et al., Cell Signal 2012 : The PKC inhibitors, GF-109203X, Gö-6983 and Ro-317549, were all found to inhibit AP-1 transcriptional activity, transcriptional activation of this minimal SOCS-3 promoter and SOCS-3 gene induction in HUVECs