UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to NGF

A2M — NGF

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: NGF → Complex of A2M-NTRK1 (decreases) Chiabrando et al., J Neurosci Res 2002 *
Evidence: It has been demonstrated that monoamine-activated forms of human and rat alpha(2)M and rat alpha(1)M can bind to TrkA and, respectively, inhibit and stimulate NGF-promoted neurite outgrowth, Trk phosphorylation, and intracellular signal transduction in PC12 cells.
OpenBEL Selventa BEL large corpus: NGF → A2M (decreases, NGF Activity)
Evidence: Monoamine-activated alpha 2-macroglobulin (alpha 2M) has been shown to inhibit beta-nerve growth factor (NGF)-promoted neurite outgrowth and the survival of embryonic sensory and forebrain neurons, whereas normal alpha 2M has little or no such activity.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: NGF — A2M (direct interaction, pull down) Gonias et al., J Biol Chem 2000 *
IRef Hprd Interaction: NGF — A2M (in vitro) Gonias et al., J Biol Chem 2000 *
IRef Innatedb Interaction: A2M — NGF (unknown, -) Wu et al., J Immunol 1998 *
IRef Ophid Interaction: A2M — NGF (aggregation, confirmational text mining) Gonias et al., J Biol Chem 2000 *
IRef Ophid Interaction: A2M — NGF (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Koo et al., J Neurosci Res 1992 : The objective of this study is to compare the NGF binding properties of methylamine modified human alpha 2M ( MA-alpha 2M ) versus normal alpha 2M and their effects on the biological activity of NGF and neurite extension by embryonic chicken dorsal root ganglia ... In contrast to normal alpha 2M, MA-alpha 2M potently inhibits the biological activity of NGF and exerts a dose dependent inhibition on the NGF stimulated neurite outgrowth by embryonic chicken dorsal root ganglia in culture
Liebl et al., J Neurosci Res 1993 : Methylamine modified alpha-2-macroglobulin ( MA-alpha 2M ) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture ( Koo PH, Liebl DJ, J Neurosci Res 31 : 678-692, 1992 )