◀ Back to RBBP4
RB1 — RBBP4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
PRMT5 (PRMT5)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(transcription, inhibits)
Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(transcription, activates)
Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
RBBP4
—
RB1
Qian et al., J Biol Chem 1995*, Qian et al., Nature 1993*
-
IRef Bind_translation Interaction:
RBBP4
—
RB1
(coimmunoprecipitation)
Qian et al., J Biol Chem 1995*
-
IRef Bind_translation Interaction:
RBBP4
—
RB1
(coimmunoprecipitation)
Qian et al., J Biol Chem 1995*, Qian et al., Nature 1993*
-
IRef Bind_translation Interaction:
RBBP4
—
RB1
(experimental interaction detection)
Qian et al., J Biol Chem 1995*
-
IRef Bind_translation Interaction:
RBBP4
—
RB1
(affinity chromatography technology)
Qian et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(physical association, affinity chromatography technology)
Nicolas et al., Nucleic Acids Res 2001
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(physical association, affinity chromatography technology)
Qian et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(physical association, affinity chromatography technology)
Nicolas et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(direct interaction, pull down)
Nicolas et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(physical association, affinity chromatography technology)
Lai et al., Mol Cell Biol 2001
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(physical association, affinity chromatography technology)
O'Connor et al., Exp Hematol 2011*
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(physical association, affinity chromatography technology)
Qian et al., Nature 1993*
-
IRef Biogrid Interaction:
RBBP4
—
RB1
(direct interaction, pull down)
Qian et al., Nature 1993*
-
IRef Hprd Interaction:
RBBP4
—
RB1
(in vitro)
Qian et al., J Biol Chem 1995*
-
IRef Hprd Interaction:
RBBP4
—
RB1
(in vivo)
Qian et al., J Biol Chem 1995*
-
IRef Intact Interaction:
Complex of 92 proteins
(association, anti tag coimmunoprecipitation)
Joshi et al., Molecular systems biology 2013
-
IRef Ophid Interaction:
RBBP4
—
RB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Finzer et al., Oncogene 2001
(Cell Transformation, Neoplastic...) :
HDAC inhibition also
triggered an E7-dependent degradation of
pRb , while the levels of E2F remained unaffected
Takaki et al., Biochem Biophys Res Commun 2004
:
Cdk mediated phosphorylation of
pRB regulates
HDAC binding in vitro ... Phosphorylation of
pRB by Cdk4-cyclin D2, Cdk2-cyclin E, and Cdk2-cyclin A
inhibited association of pRB with
HDAC