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ARSK — TNF

Text-mined interactions from Literome

Hoeflich et al., Oncogene 1999 : A truncated derivative of TRAF2, which inhibits SAPK activation by TNF, blocks TNF induced ASK1 activation
Liu et al., Mol Cell Biol 2000 : Thus, activation of ASK1 by TNF requires the ROS mediated dissociation of Trx possibly followed by the binding of TRAF2 and consequent ASK1 homo-oligomerization
Tobiume et al., EMBO Rep 2001 : Thus, ASK1 is selectively required for TNF- and oxidative stress induced sustained activations of JNK/p38 and apoptosis
Liu et al., J Clin Invest 2001 (MAP Kinase Signaling System) : Laminar flow inhibits TNF induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3 ... TNF activates ASK1 in part by dissociating ASK1 from its inhibitor 14-3-3 ... Steady laminar flow inhibited both TNF activation of ASK1 and JNK
Galvan et al., J Biol Chem 2003 : IGF-IR signaling inhibited ASK1 irrespective of TNFalpha induced ASK1 activation and resulted in decreased ASK1 dependent JNK1 stimulation
Guicciardi et al., J Clin Invest 2003 (MAP Kinase Signaling System) : Evidence now shows that the ASK1 interacting protein, AIP1, plays an important role in TNF-alpha induced ASK1 activation by facilitating dissociation from its inhibitor
Zhang et al., J Clin Invest 2003 (MAP Kinase Signaling System) : AIP1 mediates TNF-alpha induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 ... TNF-alpha activates ASK1 in part by dissociating 14-3-3 from apoptosis signal regulating kinase 1 ( ASK1 ) ... AIP1 exists in a closed form through an intramolecular interaction between the N-terminus and the C-terminus, and TNF-alpha induces unfolding of AIP1 leading to association of AIP1 with ASK1 ... Furthermore, TNF induced ASK1/JNK activation is significantly blunted in cells where AIP1 is knocked down by RNA interference ... These data suggest that AIP1 mediates TNF-alpha induced ASK1 activation by facilitating dissociation of inhibitor 14-3-3 from ASK1, a novel mechanism by which TNF-alpha activates ASK1
Zhang et al., J Biol Chem 2004 : Taken together, our data suggest that AIP1 is a novel transducer in TNF induced TRAF2 dependent activation of ASK1 that mediates a balance between JNK versus NF-kappaB signaling
Yamawaki et al., J Clin Invest 2005 (Inflammation) : In cultured ECs, reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited TNF activation of JNK/p38 and VCAM1 expression
Li et al., J Biol Chem 2005 : We have recently identified ASK1 interacting protein ( AIP1 ) as novel signal transducer in TNFalpha induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 ... Our study suggests that TNFalpha induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha induced ASK1-JNK/p38 activation
Zhang et al., J Biol Chem 2005 : Thus, our data have identified PKD as a critical mediator in H2O2- but not TNF induced ASK1-JNK signaling
He et al., J Biol Chem 2006 (Inflammation) : SOCS1 inhibits tumor necrosis factor induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation
Imoto et al., Diabetes 2006 (Carcinoma, Hepatocellular...) : These results suggest that TNF-alpha increases mitochondrial ROS and activates ASK1 in Huh7 cells and that these TNF-alpha induced phenomena contribute, at least in part, to impaired insulin signaling ... TNF-alpha significantly activated ASK1 , increased serine phosphorylation of insulin receptor substrate (IRS)-1, and decreased insulin stimulated tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt, and all of these effects were inhibited by overexpression of either UCP-1 or MnSOD
Tamura et al., Cancer Sci 2006 (Cell Transformation, Neoplastic) : Studies of TNFalpha- and H2O2 induced apoptosis revealed that ASK1 , a component of the SAPK system, mediates the TNFalpha and H2O2 signaling of apoptosis
Guilloton et al., Cell Signal 2007 (Leukemia, Myeloid, Acute) : Otherwise, TNFalpha and FasL stimulation led to radical oxygen species ( ROS ) generation and ASK1 ( Apoptosis-signal-regulating-kinase-1 ) activation
Zhang et al., J Biol Chem 2007 (MAP Kinase Signaling System) : RIP1 mediated AIP1 phosphorylation at a 14-3-3 binding site is critical for tumor necrosis factor induced ASK1-JNK/p38 activation ... Overexpression of AIP1-S604A blocks TNF induced ASK1-JNK activation ... Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for TNF induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling
Nishikawa et al., Diabetes Res Clin Pract 2007 (Hyperglycemia...) : Here we demonstrate that TNF-alpha increases mitochondrial ROS production and ASK1 activity, and that these TNF-alpha induced phenomena associate with JNK activation, increase in Ser ( 307 ) phosphorylation of IRS-1 and decrease in insulin stimulated tyrosine phosphorylation of IRS-1, all of which are believed to be the molecular basis of TNF-alpha induced insulin resistance
Li et al., Cell Death Differ 2008 : Furthermore, the wild-type form of SENP1 enhances, whereas the catalytic-inactive mutant form or siRNA of SENP1 blocks, TNF induced desumoylation and cytoplasmic translocation of HIPK1 as well as TNF induced ASK1-JNK activation
Luo et al., J Biol Chem 2008 : We have previously shown that ASK1 interacting protein 1 (AIP1) transduces tumor necrosis factor induced ASK1-JNK signaling
Min et al., Circ Res 2008 : AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor induced ASK1-JNK activation ... Endogenous AIP1-PP2A complex can be detected in the resting state, and TNF induces a complex formation of AIP1-PP2A with ASK1 ... Furthermore, TNF induced association of PP2A with ASK1 was diminished in AIP1-knockdown ECs, suggesting a critical role of AIP1 in recruiting PP2A to ASK1
Yuk et al., Immunol Cell Biol 2009 (Tuberculosis) : Furthermore, we present evidence that TNF receptor associated factor (TRAF) 6 activities were essential for ROS mediated ASK1 activation by M. bovis BCG
Yu et al., J Biol Chem 2009 : SHP2 associated with ASK1 in response to tumor necrosis factor in EC
Al-Lamki et al., Am J Transplant 2009 : In ( WT ) C57BL/6 myocardium, TNF activated both ASK1 and Etk, and increased both apoptosis and cell cycle entry
Tsou et al., J Cell Biochem 2012 (Osteoarthritis) : Stimulation of cells with TNF-a enhanced ASK1 , JNK, and p38 activation
Gotoh et al., J Biol Chem 1998 : TNFalpha induced activation of ASK1 was inhibited by antioxidants ... These results suggest that TNFalpha induced activation of ASK1 is mediated by ROS ... TNFalpha or hydrogen peroxide treatment increased the dimeric form of ASK1 , and pretreatment with N-acetylcysteine decreased it ... These results taken together suggest that TNFalpha causes ASK1 activation via ROS mediated dimerization of ASK1
Nishitoh et al., Mol Cell 1998 : A truncated derivative of TRAF2, which inhibits JNK activation by TNF, blocks TNF induced ASK1 activation ... In untransfected mammalian cells, ASK1 rapidly associates with TRAF2 in a TNF dependent manner