◀ Back to IL6
IL6 — JAK1
Pathways - manually collected, often from reviews:
-
BioCarta role of erbb2 in signal transduction and oncology:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3)
→
STAT3
(modification, activates)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
STAT3
(modification, activates)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
JAKs (JAK2/JAK1/JAK3)
(modification, collaborate)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
(modification, collaborate)
-
BioCarta il 6 signaling pathway:
JAKs (JAK2/JAK1/JAK3)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
(modification, collaborate)
-
BioCarta role of erbb2 in signal transduction and oncology:
JAKs (JAK2/JAK1/JAK3)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
(modification, collaborate)
-
BioCarta role of erbb2 in signal transduction and oncology:
JAKs (JAK2/JAK1/JAK3)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3)
(modification, collaborate)
-
BioCarta role of erbb2 in signal transduction and oncology:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3)
(modification, collaborate)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SOCS3 (SOCS3)
(modification, collaborate)
Schmitz et al., J Biol Chem 2000
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, collaborate)
Schmitz et al., J Biol Chem 2000
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
SOCS3 (SOCS3)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, collaborate)
Schmitz et al., J Biol Chem 2000
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer ) complex (STAT3)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
MITF (MITF)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
PIAS3/MITF complex (PIAS3-MITF)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family complex (GRB2-SOS1-GAB1_GAB2)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
SHP2 (PTPN11)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT1 (STAT1)
(modification, activates)
Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Gerhartz et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Gerhartz et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer ) complex (STAT3)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
FOXO1 (FOXO1)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
PIAS1 (PIAS1)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, collaborate)
Liu et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT1 (STAT1)
(modification, activates)
Liu et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT1/PIAS1 complex (STAT1-PIAS1)
(modification, activates)
Liu et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
MKK6 (MAP2K6)
(modification, activates)
Bode et al., Biol Chem 2001
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
VAV1 (VAV1)
(modification, activates)
Schuringa et al., Biochem J 2000
-
NCI Pathway Database SHP2 signaling:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
gp130 (dimer)/JAK1/JAK1/LMO4 complex (JAK1-IL6ST-LMO4)
→
IL6/IL6RA complex (IL6-IL6R)
(modification, collaborate)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
gp130 (dimer)/JAK1/JAK1/LMO4 complex (JAK1-IL6ST-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, collaborate)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
PTPEC (PTPRE)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, inhibits)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA complex (IL6-IL6R)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, collaborate)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
Hck (HCK)
(modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
Hck (HCK)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (STAT3)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
nPKC-delta (PRKCD)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
nPKC-delta (PRKCD)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
Reactome Reaction:
IL6
→
JAK1
(reaction)
Hibi et al., Cell 1990, Taga et al., Cell 1989, Hemmann et al., J Biol Chem 1996, Schaper et al., Biochem J 1998
-
Reactome Reaction:
IL6
→
JAK1
(indirect_complex)
Hibi et al., Cell 1990, Taga et al., Cell 1989
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of
JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Wang et al., Oncogene 2000
:
PD180970 did not affect MAPK activation by PDGF or the
JAK dependent
activation of Stat3 by
interleukin-6
Tanuma et al., J Biol Chem 2000
(Leukemia, Myeloid, Acute) :
PTPepsilonC expression resulted in lower levels of
IL-6 induced tyrosine phosphorylation of
Jak1 , Tyk2, gp130, and Stat3 compared with parent cells
Iwamoto et al., Oncogene 2000
(Acute-Phase Reaction) :
Furthermore, in vitro kinase assay indicated that JAB suppressed hyperactivation of
JAK1/JAK2 and JAK1
induced by IFNgamma and
IL-6 plus sIL-6R respectively, but not v-Src induced basal JAK1/JAK2 activity
Song et al., Zhonghua Xue Ye Xue Za Zhi 2000
(Multiple Myeloma) :
The biological function of
IL-6 on Sko-007 cells is
mediated by the activation of
Jak/STAT and Ras/NF-IL-6 signal transduction pathways
Kuo et al., Oncogene 2001
:
In Hep3B cells, the
JAK/STAT3 , ERK, and PI 3-K/Akt pathways were
activated by
IL-6 stimulation
Song et al., Zhonghua Zhong Liu Za Zhi 2001
(Multiple Myeloma) :
( 1 ) IL-6 could promote the proliferation of U266 cells, ( 2 ) both
JAK/STAT and Ras/NF-IL-6 signal transduction pathways were
activated by
IL-6 in the U266 cells and ( 3 ) Cell proliferation and activation of the two IL-6 signal transduction pathways were inhibited by Forskolin ; down regulating the actiration of these two signal transduction pathways at the same time
Ling et al., Crit Care Med 2002
:
In endotoxin treated rats, there was significant inhibition of
interleukin-6 activation of
janus kinase-1 , gp 130, the interleukin-6 receptor, STAT1, and STAT3
Legendre et al., J Biol Chem 2003
:
JAK/STAT but not ERK1/ERK2 pathway
mediates interleukin (IL)-6/soluble
IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes ... In the present study, we show for the first time that
interleukin-6 (IL) , in the presence of its soluble receptor ( sIL-6R ),
induces activation of
JAK1 , JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
Zancai et al., Int J Oncol 2004
:
These changes, however, were not related to the enhanced production of endogenous IL-6 induced by RA in LCLs. RA-induced modulation of IL-6 receptor components did not abolish IL-6 mediated phosphorylation of gp130, whereas
JAK1 and STAT3 phosphorylation and activation
induced by
IL-6 were markedly inhibited
Siavash et al., Br J Cancer 2004
(Carcinoma, Squamous Cell...) :
Abrogation of
IL-6 mediated
JAK signalling by the cyclopentenone prostaglandin 15d-PGJ ( 2 ) in oral squamous carcinoma cells ... Importantly, 15d-PGJ ( 2 ) selectively abrogated constitutive and
IL-6 mediated
JAK phosphorylation without affecting EGFR activated levels ... Our findings provide the first evidence for 15d-PGJ ( 2 ) -mediated downregulation of constitutive and
IL-6 induced
JAK signalling in cancer and support that JAK inhibition and suppression of EGFR independent Stat3 activation by 15d-PGJ ( 2 ) represent a promising approach for induction of apoptosis in oral SCC cells
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Dawn et al., Cardiovasc Res 2004
(Myocardial Infarction...) :
Myocardial
IL-6 protein expression,
activation of
Janus kinase (JAK) 1 and JAK2, and signal transducers and activators of transcription ( STAT ) 1 and STAT3 after ischemic PC protocol were examined
Kimura et al., Proc Natl Acad Sci U S A 2005
:
Suppressor of cytokine signaling-1 selectively
inhibits LPS induced
IL-6 production by regulating
JAK-STAT
Lee et al., Mol Cancer Ther 2006
(Carcinoma, Squamous Cell...) :
We conclude that SOCS-1 methylation status can differentially affect STAT3
activation by
IL-6R and EGFR through
JAK or MEK in different HNSCC and response to pharmacologic antagonists
O'Hara et al., Biochem J 2007
:
Inhibition with siRNA ( small interfering RNA ) targeting the SFK Lck, but not dominant negative
JAK ( Janus kinase ),
prevented Cr ( VI ) -stimulated phosphorylation of both STAT3 isoforms and induction of
IL-6
Kim et al., Immunology 2007
(Arthritis, Rheumatoid) :
In HepG2 human hepatoma cells, AF markedly inhibited
IL-6 induced phosphorylation of
janus kinase 1 (JAK1) and signal transducer and activator of transcription 3 ( STAT3 ) and STAT3 translocation into the nucleus
Ahmad et al., Cancer Res 2008
(Breast Neoplasms) :
The present studies show that CDDO-Me blocks
interleukin-6 (IL-6) induced and constitutive
activation of the
Janus activated kinase 1 (JAK1) in cells
Canellada et al., J Steroid Biochem Mol Biol 2008
:
We found that the
IL-6 treatment
induced an increase in the expression of gp130 and
JAK1 by the hybridoma
Gong et al., Mol Nutr Food Res 2009
(Prostatic Neoplasms) :
Moreover, an antioxidant reagent, N-acetyl-L-cysteine (NAC) which suppresses reactive oxygen species ( ROS ) generation, reversed the early inhibitory effects of PEITC on cell proliferation, constitutive or
IL-6 mediated
JAK-STAT3 phosphorylation in PCa cells
Radtke et al., J Cell Sci 2010
:
We show that p38, activated by IL-1beta, TNFalpha or environmental stress, impairs
IL-6 induced
JAK/STAT signalling through phosphorylation of the common cytokine receptor subunit gp130 and its subsequent internalisation and degradation
Tanabe et al., Journal of neuroinflammation 2010
(Glioma) :
The
Janus family of tyrosine kinase ( JAK ) inhibitor I, an inhibitor of JAK 1, 2 and 3, attenuated TNF-alpha induced phosphorylation of STAT3 and significantly
reduced TNF-alpha stimulated
IL-6 release
Liu et al., Neurotox Res 2011
:
These results suggest that
IL-6 protects neurons against NMDA induced apoptosis, and that the IL-6 neuroprotection is jointly
mediated by
JAK-STAT3 and PI3K-Akt signaling pathways
Ngo et al., Nature 2011
(Burkitt Lymphoma...) :
The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity, IRAK1 phosphorylation, NF-?B signalling,
JAK kinase
activation of STAT3, and secretion of
IL-6 , IL-10 and interferon-ß
Tanabe et al., Journal of neuroinflammation 2011
:
The IL-1ß stimulated levels of
IL-6 were
suppressed by wedelolactone ( an inhibitor of I?B kinase ), SP600125 ( an inhibitor of SAPK/JNK ), and
JAK inhibitor I ( an inhibitor of JAK 1, 2 and 3 )
Dittrich et al., Molecular bioSystems 2012
:
Misregulated
interleukin-6 (IL-6) induced
Jak/STAT signaling contributes to many diseases
Nam et al., J Pept Sci 2012
:
Inhibition of
JAK ( STAT1/STAT5 kinase ) with AG490 markedly
reduced the production of
IL-6 and TNF-a in macrophages
Soth et al., J Med Chem 2013
:
Evaluation of this analogue in cellular and in vivo models confirmed functional selectivity for modulation of a JAK3/JAK1 dependent IL-2 stimulated pathway over a
JAK1/JAK2/Tyk2 dependent
IL-6 stimulated pathway
Follin-Arbelet et al., Cancer Lett 2013
(Multiple Myeloma) :
Notably, exogenous
interleukin-6 neither
prevented the inhibition of
JAK1/STAT3 nor the death of MM cells induced by cAMP
Russell et al., Islets 2013
:
Differential
effects of interleukin-13 and
interleukin-6 on
Jak/STAT signaling and cell viability in pancreatic ß-cells
Lai et al., PloS one 2013
:
Additionally,
IL-6 mediated angiotensinogen expression through the Janus kinase ( JAK ) /signal transducer and activator of transcription 3 ( STAT3 ) and
JAK/p38 signaling ...
IL-6 mediated signaling,
JAK2 , STAT3 and p38 inhibitors reduced angiotensinogen expression in the partially hepatectomized mice
Faris et al., Immunology 1997
:
We have previously shown that
IL-6 induces activation of
JAK1 and JAK2 in human B cell lines
Leven et al., Blood Cells Mol Dis 1997
:
Studies on protein phosphorylation revealed that
IL6 , but not TPO,
stimulated phosphorylation of JAK1,
JAK2 and MAP kinase
Sengupta et al., Proc Natl Acad Sci U S A 1998
:
These results demonstrate an ERK mediated mechanism for inhibiting
IL-6 induced
Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway