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IL22 — IRF4

Text-mined interactions from Literome

Mudter et al., Inflamm Bowel Dis 2011 (Colitis...) : In contrast to DSS colitis, IRF4 deficiency was protective in T-cell dependent transfer colitis associated with reduced RORa/?t levels and impaired IL-6, IL-17a, and IL-22 production, suggesting that IRF4 acts as a master regulator of mucosal Th17 cell differentiation
Valdez et al., Immunity 2012 (Cryptococcosis) : We show that IRF4 was required for IL-17 expression but inhibited IL-22 expression, highlighting the potential for discordant regulation of these two cytokines in Th17 cells
Raifer et al., Eur J Immunol 2012 (Encephalomyelitis, Autoimmune, Experimental) : Unlike aß T cells, ?d T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22