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CIB1 — PAK1

Text-mined interactions from Literome

Leisner et al., J Cell Biol 2005 : Essential role of CIB1 in regulating PAK1 activation and cell migration ... CIB1 binds to PAK1 within discrete regions surrounding the inhibitory switch domain in a calcium dependent manner, providing a potential mechanism of CIB1 induced PAK1 activation ... Conversely, the RNA interference mediated depletion of CIB1 increases cell migration and reduces normal adhesion induced PAK1 activation and cofilin phosphorylation ... Together, these results demonstrate that endogenous CIB1 is required for regulated adhesion induced PAK1 activation and preferentially induces a PAK1 dependent pathway that can negatively regulate cell migration
Zayed et al., Circ Res 2007 (Ischemia...) : Ischemic CIB1-/- hindlimbs also demonstrate increased tissue damage and significantly reduced p21 activated kinase 1 activation