Gene interactions and pathways from curated databases and text-mining

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PAK1 — RNF19A

Text-mined interactions from Literome

Lee et al., J Biol Chem 2001 : This betaPix induced p38 activation was blocked by coexpression of dominant negative Cdc42/Rac or kinase-inactive PAK , indicating that the effect of betaPix on p38 is exerted through the Cdc42/Rac-PAK pathway and requires PAK kinase activity
Dechert et al., Am J Physiol Cell Physiol 2001 (MAP Kinase Signaling System) : Phosphorylation of p38 mitogen activated protein kinase ( MAPK ) in cells overexpressing wild-type PAK1 was similar to vector controls ; however, p38 MAPK phosphorylation was severely reduced by overexpression of the PAK1 mutant
Chan et al., J Biol Chem 2008 (MAP Kinase Signaling System) : Inhibition of MAPK pathways showed that MEK-ERK signaling but not p38 is required for full PAK activation and focal adhesion turnover
Huang et al., Mol Cell Biol 1998 : These data indicate that separate signals are required for activation and inactivation of Paks and that, in contrast to other cell types, activated Pak does not trigger activation of JNK or p38-MAPK in neutrophils