Gene interactions and pathways from curated databases and text-mining

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IL17D — IL22

Text-mined interactions from Literome

Shen et al., Scand J Rheumatol 2013 (Behcet Syndrome...) : Elevated levels of interleukin-27 and effect on production of interferon-? and interleukin-17 in patients with Behçet 's disease
Wang et al., Immunol Lett 2013 : In the present study, we demonstrate that IL-27 inhibits the production of IL-22 and induces the expression of IFN-? in CD4 ( + ) T cells from human umbilical cord blood mononuclear cells ( CBMCs ) stimulated with anti-CD3 and anti-CD28 in dose dependent manner ... Moreover, IL-27 inhibits the production of IL-22 in CD4 ( + ) CD45RA ( + ) and CD4 ( + ) CD45RO ( + ) T cells from PBMCs ... These data identify that IL-27 may suppress the production of IL-22 by inducing the expression of SOCS1 in human CD4 ( + ) T cells