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GHRH — PRKACG
Text-mined interactions from Literome
Lei et al., J Tongji Med Univ 2000
(Adenoma...) :
In order to investigate the relationship between abnormal intracellular signal transduction and tumorgenesis of human pituitary somatotrophinomas, the effects of
protein kinase A (PKA) dependent
growth hormone (GH) releasing hormone ( GHRH ) and protein kinase C ( PKC ) -dependent GH-releasing peptide ( GHRP-6 ) on cAMP production were observed by using cell culture and biochemical methods, and the expression of the gsp oncogene was detected by using PCR and direct sequence assay methods in 11 patients with human pituitary somatotrophinomas
Pombo et al., Horm Res 2001
:
It is well established that binding of
GHRH to its receptor
leads to activation of
protein kinase A (PKA)
Wong et al., Neuroendocrinology 1995
:
Somatostatin ( SRIF) (1 nM ), the physiological GH-release inhibitor, suppressed the GH response to GRF without affecting the basal or
GRF stimulated
PKA activity ... In this case, SRIF also induced a small but significant inhibition of
GRF stimulated
PKA activity