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IFNB1 — MMP9

Text-mined interactions from Literome

Smeets et al., Arthritis Rheum 2000 (Arthritis, Rheumatoid...) : To further assess the mechanism of action, in vitro experiments were conducted to determine the effects of IFNbeta on the production of MMP-1, MMP-3 , tissue inhibitor of metalloproteinases 1 ( TIMP-1 ), and prostaglandin E2 ( PGE2 ) by human fibroblast-like synoviocytes ( FLS ) ... In addition, we measured the production of MMP-1, MMP-3 , TIMP-1, and PGE2 by RA FLS and dermal fibroblasts in the presence and absence of IFNbeta
Ma et al., J Immunol 2001 : We investigated the effects of IFN-gamma and IFN-beta , cytokines used for treating some cancers and multiple sclerosis, on MMP-9 expression in human astroglioma and fibrosarcoma cell lines and primary astrocytes ... Our results demonstrate that IFN-gamma and IFN-beta significantly inhibit MMP-9 enzymatic activity and protein expression that is induced by PMA and the cytokine TNF-alpha ... The inhibitory effects of IFN-gamma and IFN-beta on MMP-9 expression correlate with decreased steady state MMP-9 mRNA levels and suppression of MMP-9 promoter activity ... IFN-gamma- and IFN-beta mediated inhibition of MMP-9 gene expression is dependent on the transcription factor STAT-1alpha, since IFN-gamma and IFN-beta fail to suppress MMP-9 expression in STAT-1alpha-deficient primary astrocytes and human fibrosarcoma cells ... Reconstitution of human STAT-1alpha successfully restores the inhibitory effects of IFN-gamma and IFN-beta on MMP-9 gene expression
Nelissen et al., J Leukoc Biol 2002 : To investigate whether a functional link exists between PECAM-1 activation and gelatinase B production, the regulatory role of PECAM-1, IFN-gamma, IFN-beta , LPS, and PMA on the production of gelatinase B ( MMP-9 ) was studied in vitro in normal human umbilical vein endothelial cells ( HUVECs ), human peripheral blood mononuclear cells ( PBMCs ), and in a human monocytic leukemia cell line ... IFN-beta inhibited the induced and basal gelatinase B production but had no modulating effect on the expression of PECAM-1 ... Finally, in PBMCs, progelatinase B production was increased by soluble PECAM-1 mAb, recombinant PECAM-1, LPS, and PMA, whereas IFN-beta reduced gelatinase B secretion
Nelissen et al., Brain 2003 (Multiple Sclerosis) : Furthermore, the tetracycline minocycline, which has a known blocking effect in experimental autoimmune encephalomyelitis, an in vivo model of acute inflammation in multiple sclerosis, and other MMP inhibitors prevent the in vitro degradation of IFN-beta by gelatinase B
Dubois et al., J Neurol 2003 (Multiple Sclerosis, Chronic Progressive) : Although some evidence suggests a down regulating effect of IFNbeta on MMP-9 , this was not confirmed for a once weekly intramuscular dose of IFNbeta-1a in patients with PPMS
Karabudak et al., J Neurol 2004 (Multiple Sclerosis, Relapsing-Remitting) : In this present study, the effects of IFNbeta-1a on serum MMP-9 and TIMP-1 were evaluated longitudinally during a one-year period
Ben-Hur et al., J Neuroimmunol 2006 : IFN-beta suppressed the TNF-alpha induced levels of secreted MMP-9 and MMP-2, while enhancing the expression of TIMP-1 and TIMP-2 mRNA
Du et al., J Neuroimmunol 2010 (Disease Models, Animal...) : Additionally, combination treatment reduced VLA-4 expression on CD4+ T cells, while it abrogated IFNbeta mediated decreases in MMP-9
Yen et al., J Immunol 2010 : In vivo treatment with IFN-beta results in lower numbers of DCs migrating to the draining lymph node following exposure to FITC and in reduced expression of CCR7 and MMP-9 in splenic CD11c ( + ) DCs following LPS administration