Gene interactions and pathways from curated databases and text-mining

◀ Back to JUN

ATF2 — JUN

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sabbah et al., Proc Natl Acad Sci U S A 1999 : To interpret these results, we propose a mechanism in which ATF-2/c-Jun heterodimers bind to the CRE-D1 element and mediate the activation of cyclin D1 promoter by the ER
Kim et al., J Biol Chem 2000 : Taken together with previous observations, these results implicate that, for the assembly of an IFN-beta enhanceosome, MEKK1 can induce IRF3 and ATF2/c-JUN through the JNK pathway, whereas it can induce NF-kappaB through the IKK pathway ... Taken together with previous observations, these results implicate that, for the assembly of an IFN-beta enhanceosome, MEKK1 can induce IRF3 and ATF2/c-JUN through the JNK pathway, whereas it can induce NF-kappaB through the IKK pathway
Steer et al., J Biol Chem 2000 : LPS increased nuclear c-Jun/ATF-2 , NF-kappaB ( 1 ) /Rel-A, and Rel-A/C-Rel transcription factor complexes, which bound specifically to oligonucleotide sequences from the -106 to -88 base pair ( bp ) region of the promoter
Fan et al., Cancer Res 2001 : KB3-TAM67 cell lines displayed normal growth kinetics and essentially unaltered basal AP-1 activity, but vinblastine induced phosphorylation of c-Jun and activating transcription factor-2 , and AP-1 activation, were strongly inhibited
Castro-Rivera et al., J Biol Chem 2001 (Breast Neoplasms) : These results contrasted to a recent report showing that induction of cyclin D1 by E2 in ER-positive MCF-7 and HeLa cells was due to up-regulation of c-jun and subsequent interaction of c-Jun-ATF-2 with the CRE
Mao et al., J Immunol 2001 : Furthermore, the bZip elements of the two promoters bind different transcription factors, as the GL epsilon promoter binds and is activated by AP-1 , whereas the gamma1 promoter binds and is activated by activating transcription factor 2
Steinmüller et al., Biochem J 2001 (Carcinoma, Hepatocellular...) : In contrast, constitutive c-Jun promoter activity was blocked solely by A-ATF2 , strongly suggesting that ATF2 and/or an ATF2 dimerizing protein are of major importance for c-Jun transcription in unstimulated cells
Bhoumik et al., J Clin Invest 2002 (Melanoma...) : Here we demonstrate that the expression of a peptide spanning amino acids 50-100 of ATF2 ( ATF2 ( 50-100 ) ) reduces ATF2 transcriptional activities while increasing the expression and activity of c-Jun ... Inhibition of ATF2 via RNA interference likewise increased c-Jun expression and primed melanoma cells to undergo apoptosis
Rahaus et al., Virus Res 2003 : Reciprocal effects of varicella-zoster virus ( VZV ) and AP1 : activation of jun, fos and ATF-2 after VZV infection and their importance for the regulation of viral genes
Steinmüller et al., Biol Chem 2003 : The transcriptional activity of the constitutively active ATF2 mutant could be impaired by dominant negative forms of ATF2 or c-Jun , indicating that ATF2 and c-Jun utilize a similar dimerization code
Papassava et al., Cancer Res 2004 (Carcinoma...) : Subsequently, we observed that dominant negative ATF-2 affected the composition and reduced the activity of AP-1
Faour et al., J Biol Chem 2005 (Arthritis, Rheumatoid) : PGE2 suppression of IL-17 induced ATF-2/c-Jun transactivation and DNA binding was dependent on Egr-1 mediated inhibition of induced c-Jun expression ... PGE2 suppression of IL-17 induced ATF-2/c-Jun transactivation and DNA binding was dependent on Egr-1 mediated inhibition of induced c-Jun expression
Liu et al., EMBO J 2006 : Importantly, c-Jun dependent nuclear localization of ATF2 occurs during retinoic acid induced differentiation and UV-induced cell death in F9 cells
Kim et al., Cancer Lett 2007 (Breast Neoplasms...) : TGF-beta increased DNA binding activity of AP-1 in which ATF2 was involved as evidenced by electrophoretic mobility shift assay
Samten et al., J Immunol 2008 : Additionally, ATF-2 controls expression of CREB and c-Jun during T cell activation
Liu et al., Cancer Res 2009 (Mammary Neoplasms, Experimental) : Activating transcription factor 2 and c-Jun mediated induction of FoxP3 for experimental therapy of mammary tumor in the mouse
Daffis et al., PLoS Pathog 2009 (West Nile Fever) : However, pharmacological inhibition of NF-kappaB and ATF-2/c-Jun , the two other known components of the IFN-beta enhanceosome, strongly reduced IFN-beta gene transcription in the DKO dendritic cells
Fu et al., J Biol Chem 2011 (Carcinoma, Hepatocellular...) : The increased expression of c-JUN was dependent on ATF2 and on activation of the MEK-ERK and JNK arms of the MAPK signaling pathways
Lu et al., J Dermatol 2013 : Importantly, JUN may regulate activating transcription factor 3 expression to involve cell proliferation process ; STAT1 and STAT3 can inhibit tissue inhibitor of metalloproteinases-3 expression to modulate the cell adhesion molecule pathway ; NF-?B and E2F1 can downregulate cyclin D1, but upregulate proliferating cell nuclear antigen expression to promote the cell cycle pathway
Lindaman et al., Mol Cell Endocrinol 2013 (MAP Kinase Signaling System) : Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotrope ... Functional ATF2 is necessary for both GnRH induction of c-Jun and FSHß
Sjöblom et al., J Virol 1998 : In contrast, the ATF-2/c-Jun heterodimer had only a minor stimulatory effect in the absence of EBNA2 but induced a strong transactivation of the LMP1 promoter when coexpressed with this protein
Pober et al., Pathol Biol (Paris) 1998 : Activation of c-Jun/ATF-2 involves new c-Jun synthesis, and more importantly, phosphorylation of the amino terminus of c-Jun by Jun N-terminal kinase (JNK)
Yi et al., J Immunol 1998 (Lymphoma, B-Cell) : CpG DNA also induces the phosphorylation of activating transcription factor-2 , c-Jun, and mitogen activated protein kinase ( MAPK) activated protein kinase 2 as well as the activation of activator protein-1 (AP-1) DNA binding
Huguier et al., Mol Cell Biol 1998 (Neoplasms, Experimental) : Experiments were designed to evaluate a possible role of ATF2 in oncogenesis in chick embryo fibroblasts ( CEFs ) in the presence or absence of v-Jun
Biswas et al., EMBO J 1999 (Calcium Signaling) : The mitochondrial stress resulted in : ( i ) an enhanced expression of the sarcoplasmic reticular ryanodine receptor-1 (RyR-1), hence potentiating the Ca2+ release in response to its modulator, caffeine ; ( ii ) enhanced levels of Ca2+-responsive factors calineurin, calcineurin dependent NFATc ( cytosolic counterpart of activated T-cell-specific nuclear factor ) and c-Jun N-terminal kinase (JNK) dependent ATF2 ( activated transcription factor 2); (iii ) reduced levels of transcription factor, NF-kappaB ; and ( iv ) enhanced transcription of cytochrome oxidase Vb (COX Vb) subunit gene