◀ Back to JUN
ATF2 — JUN
Pathways - manually collected, often from reviews:
-
BioCarta the 41bb-dependent immune response:
c-JUN (JUN)
→
ATF-2 (ATF2)
(transcription, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
ATF-2 (ATF2)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
ATF-2 (ATF2)
→
c-JUN (JUN)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
HMG1 (HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50 complex (RELA)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
c-JUN (JUN)
(modification, collaborate)
-
BioCarta the 41bb-dependent immune response:
c-JUN (JUN)
→
ATF-2 (ATF2)
(transcription, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
PCAF
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
PCAF
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
histone transacetylase (CREBBP)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
histone transacetylase (CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
MEF2 (MEF2C/MEF2B/MEF2D/MEF2A)
→
c-JUN/ATF-2 complex (JUN-ATF2)
(transcription, activates)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the 41bb-dependent immune response:
c-JUN (JUN)
→
ATF-2 (ATF2)
(transcription, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
c-JUN (JUN)
→
ATF-2 (ATF2)
(modification, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
c-JUN (JUN)
→
c-JUN/ATF-2 complex (JUN-ATF2)
(modification, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
ATF-2 (ATF2)
→
c-JUN/ATF-2 complex (JUN-ATF2)
(modification, collaborate)
-
FastForward regulation:
ATF2
→
JUN
(transcriptional regulation, increase)
Steinmüller et al., Biol Chem 2003*
Evidence: REG
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ELAM1 (SELE)
(transcription, activates)
Read et al., J Biol Chem 1997*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ER alpha (ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ATF2/JUN/ER alpha complex (ATF2-JUN-ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
ER alpha (ESR1)
→
ATF2/JUN/ER alpha complex (ATF2-JUN-ESR1)
(modification, collaborate)
Lambertini et al., J Cell Physiol 2008*
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
ATF2 (ATF2)
→
JUN (JUN)
(modification, collaborate)
Hai et al., Proc Natl Acad Sci U S A 1991
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
ATF2 (ATF2)
→
ATF2/JUN complex (JUN-ATF2)
(modification, collaborate)
Hai et al., Proc Natl Acad Sci U S A 1991
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN (JUN)
→
ATF2/JUN complex (JUN-ATF2)
(modification, collaborate)
Hai et al., Proc Natl Acad Sci U S A 1991
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
IL23A (IL23A)
(transcription, activates)
Al-Salleeh et al., J Immunol 2008*, Liu et al., J Biol Chem 2009*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
ATF2 (ATF2)
→
c-Jun (JUN)
(modification, collaborate)
van Dam et al., EMBO J 1995*
Evidence: mutant phenotype
-
NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
ATF2 (ATF2)
→
ATF2/c-Jun complex (ATF2-JUN)
(modification, collaborate)
van Dam et al., EMBO J 1995*
Evidence: mutant phenotype
-
NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
c-Jun (JUN)
→
ATF2/c-Jun complex (ATF2-JUN)
(modification, collaborate)
van Dam et al., EMBO J 1995*
Evidence: mutant phenotype
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
IFN-gamma (IFNG)
(transcription, activates)
Penix et al., J Biol Chem 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
DP5 (HRK)
(transcription, activates)
Yuan et al., Mol Cell Biol 2009*, Towers et al., Nucleic Acids Res 2009*
Evidence: assay, reporter gene
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
MKP1 (DUSP1)
(transcription, activates)
Breitwieser et al., Genes Dev 2007*, Kristiansen et al., J Neurosci 2010*
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
JUN (JUN)
(transcription, activates)
Liu et al., EMBO J 2006*, Yuan et al., Mol Cell Biol 2009*, van Dam et al., EMBO J 1995*, van Dam et al., EMBO J 1993*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
Ggamma globin (HBG2)
(transcription, activates)
Kodeboyina et al., Blood Cells Mol Dis 2010*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database RhoA signaling pathway:
JUN/ATF2 complex (JUN-ATF2)
→
JUN (JUN)
(transcription, activates)
Marinissen et al., Mol Cell 2004*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ARG1 (ARG1)
(transcription, activates)
Liu et al., J Biol Chem 2009*, Zhu et al., Am J Physiol Cell Physiol 2010*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ACHE (ACHE)
(transcription, activates)
Zhang et al., Cell Mol Life Sci 2008*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
HES1 (HES1)
(transcription, activates)
Sanalkumar et al., J Neurochem 2010*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
ATF2 (ATF2)
→
JUN (JUN)
(transcription, activates)
Jin et al., Mol Cell Biol 2002*, Yamasaki et al., J Biol Chem 2009*, Kawasaki et al., Genes Dev 1998*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
JUN/FOS complex (FOS-JUN)
(transcription, activates)
Cirillo et al., Mol Cell Biol 1999*, De Cesare et al., Oncogene 1995*, D'Orazio et al., Gene 1997*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
uPA (PLAU)
(transcription, activates)
Cirillo et al., Mol Cell Biol 1999*, De Cesare et al., Oncogene 1995*, D'Orazio et al., Gene 1997*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
COL24A1 (COL24A1)
(transcription, activates)
Matsuo et al., J Biol Chem 2006*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
BCL-XL (BCL2L1)
(transcription, activates)
Salameh et al., J Biol Chem 2010*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
ATF3 (ATF3)
(transcription, activates)
Kool et al., Oncogene 2003*, Yuan et al., Mol Cell Biol 2009*, Chaveroux et al., Mol Cell Biol 2009*
Evidence: assay, reporter gene
-
NCI Pathway Database ATF-2 transcription factor network:
ATF2 (ATF2)
→
JUN/ATF2 complex (JUN-ATF2)
(modification, collaborate)
Fuchs et al., Mol Cell Biol 1999*, Liu et al., EMBO J 2006*, Hai et al., Proc Natl Acad Sci U S A 1991, van Dam et al., EMBO J 1995*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
ATF2 (ATF2)
→
JUN (JUN)
(modification, collaborate)
Fuchs et al., Mol Cell Biol 1999*, Liu et al., EMBO J 2006*, Hai et al., Proc Natl Acad Sci U S A 1991, van Dam et al., EMBO J 1995*
Evidence: physical interaction
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
JUN (JUN)
(modification, collaborate)
Fuchs et al., Mol Cell Biol 1999*, Liu et al., EMBO J 2006*, Hai et al., Proc Natl Acad Sci U S A 1991, van Dam et al., EMBO J 1995*
Evidence: physical interaction
-
NCI Pathway Database RhoA signaling pathway:
ATF2 (ATF2)
→
JUN/ATF2 complex (JUN-ATF2)
(modification, collaborate)
Marinissen et al., Mol Cell 2004*
Evidence: physical interaction
-
NCI Pathway Database RhoA signaling pathway:
ATF2 (ATF2)
→
JUN (JUN)
(modification, collaborate)
Marinissen et al., Mol Cell 2004*
Evidence: physical interaction
-
NCI Pathway Database RhoA signaling pathway:
JUN/ATF2 complex (JUN-ATF2)
→
JUN (JUN)
(modification, collaborate)
Marinissen et al., Mol Cell 2004*
Evidence: physical interaction
-
Reactome Reaction:
JUN
→
ATF2
(reaction)
Ainbinder et al., Eur J Biochem 1997*
-
Reactome Reaction:
JUN
→
ATF2
(direct_complex)
Ainbinder et al., Eur J Biochem 1997*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
ATF2
—
JUN
Newman et al., Science 2003
-
IRef Bind_translation Interaction:
ATF2
—
JUN
(array technology)
Newman et al., Science 2003
-
IRef Biogrid Interaction:
ATF2
—
JUN
(physical association, affinity chromatography technology)
Miyamoto-Sato et al., PloS one 2010
-
IRef Biogrid Interaction:
ATF2
—
JUN
(physical association, affinity chromatography technology)
Fuchs et al., Mol Cell Biol 1999*
-
IRef Biogrid Interaction:
ATF2
—
JUN
(direct interaction, fluorescent resonance energy transfer)
Reinke et al., Science 2013
-
IRef Biogrid Interaction:
ATF2
—
JUN
(direct interaction, pull down)
Hai et al., Proc Natl Acad Sci U S A 1991
-
IRef Biogrid Interaction:
ATF2
—
JUN
(physical association, affinity chromatography technology)
Newell et al., J Leukoc Biol 1994*
-
IRef Biogrid Interaction:
ATF2
—
JUN
(direct interaction, pull down)
Kara et al., Mol Cell Biol 1990*
-
IRef Hprd Interaction:
ATF2
—
JUN
(in vivo)
Liu et al., EMBO J 2006*, Hai et al., Proc Natl Acad Sci U S A 1991, Kara et al., Mol Cell Biol 1990*, Sjöblom et al., J Virol 1998*
-
IRef Hprd Interaction:
ATF2
—
JUN
(in vitro)
Liu et al., EMBO J 2006*, Hai et al., Proc Natl Acad Sci U S A 1991, Kara et al., Mol Cell Biol 1990*, Sjöblom et al., J Virol 1998*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Vallian et al., Oncogene 1998*
-
IRef Intact Interaction:
Complex of JUN-JDP2-ATF2
(association, anti tag coimmunoprecipitation)
Kimura et al., FEBS Lett 2008
-
IRef Intact Interaction:
ATF2
—
JUN
(physical association, coimmunoprecipitation)
Duyndam et al., Oncogene 1999*
-
IRef Intact Interaction:
ATF2
—
JUN
(physical association, tandem affinity purification)
Miyamoto-Sato et al., PloS one 2010
-
IRef Intact Interaction:
ATF2
—
JUN
(physical association, display technology)
Miyamoto-Sato et al., PloS one 2010
-
IRef Ophid Interaction:
ATF2
—
JUN
(aggregation, confirmational text mining)
Hai et al., Proc Natl Acad Sci U S A 1991
-
IRef Ophid Interaction:
ATF2
—
JUN
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Sabbah et al., Proc Natl Acad Sci U S A 1999
:
To interpret these results, we propose a mechanism in which
ATF-2/c-Jun heterodimers bind to the CRE-D1 element and
mediate the activation of
cyclin D1 promoter by the ER
Kim et al., J Biol Chem 2000
:
Taken together with previous observations, these results implicate that, for the assembly of an IFN-beta enhanceosome,
MEKK1 can
induce IRF3 and
ATF2/c-JUN through the JNK pathway, whereas it can induce NF-kappaB through the IKK pathway ... Taken together with previous observations, these results implicate that, for the assembly of an IFN-beta enhanceosome, MEKK1 can
induce IRF3 and
ATF2/c-JUN through the JNK pathway, whereas it can induce
NF-kappaB through the IKK pathway
Steer et al., J Biol Chem 2000
:
LPS increased nuclear
c-Jun/ATF-2 , NF-kappaB ( 1 ) /Rel-A, and Rel-A/C-Rel transcription factor complexes, which bound specifically to oligonucleotide sequences from the -106 to -88 base pair ( bp ) region of the promoter
Fan et al., Cancer Res 2001
:
KB3-TAM67 cell lines displayed normal growth kinetics and essentially unaltered basal
AP-1 activity, but vinblastine induced phosphorylation of c-Jun and
activating transcription factor-2 , and AP-1 activation, were strongly
inhibited
Castro-Rivera et al., J Biol Chem 2001
(Breast Neoplasms) :
These results contrasted to a recent report showing that induction of
cyclin D1 by E2 in ER-positive MCF-7 and HeLa cells was
due to up-regulation of c-jun and subsequent interaction of
c-Jun-ATF-2 with the CRE
Mao et al., J Immunol 2001
:
Furthermore, the bZip elements of the two promoters bind different transcription factors, as the GL epsilon promoter binds and is activated by
AP-1 , whereas the gamma1 promoter binds and is
activated by
activating transcription factor 2
Steinmüller et al., Biochem J 2001
(Carcinoma, Hepatocellular...) :
In contrast, constitutive
c-Jun promoter activity was
blocked solely by
A-ATF2 , strongly suggesting that ATF2 and/or an ATF2 dimerizing protein are of major importance for c-Jun transcription in unstimulated cells
Bhoumik et al., J Clin Invest 2002
(Melanoma...) :
Here we demonstrate that the expression of a peptide spanning amino acids 50-100 of
ATF2 ( ATF2 ( 50-100 ) )
reduces ATF2 transcriptional activities while increasing the expression and activity of
c-Jun ... Inhibition of
ATF2 via RNA interference likewise
increased c-Jun expression and primed melanoma cells to undergo apoptosis
Rahaus et al., Virus Res 2003
:
Reciprocal effects of varicella-zoster virus ( VZV ) and
AP1 :
activation of jun, fos and
ATF-2 after VZV infection and their importance for the regulation of viral genes
Steinmüller et al., Biol Chem 2003
:
The transcriptional activity of the constitutively active
ATF2 mutant could be
impaired by dominant negative forms of ATF2 or
c-Jun , indicating that ATF2 and c-Jun utilize a similar dimerization code
Papassava et al., Cancer Res 2004
(Carcinoma...) :
Subsequently, we observed that dominant negative
ATF-2 affected the composition and
reduced the activity of
AP-1
Faour et al., J Biol Chem 2005
(Arthritis, Rheumatoid) :
PGE2 suppression of
IL-17 induced
ATF-2/c-Jun transactivation and DNA binding was dependent on Egr-1 mediated inhibition of induced c-Jun expression ... PGE2 suppression of IL-17 induced
ATF-2/c-Jun transactivation and DNA binding was
dependent on Egr-1 mediated inhibition of induced
c-Jun expression
Liu et al., EMBO J 2006
:
Importantly,
c-Jun dependent nuclear localization of
ATF2 occurs during retinoic acid induced differentiation and UV-induced cell death in F9 cells
Kim et al., Cancer Lett 2007
(Breast Neoplasms...) :
TGF-beta increased DNA binding activity of
AP-1 in which
ATF2 was
involved as evidenced by electrophoretic mobility shift assay
Samten et al., J Immunol 2008
:
Additionally,
ATF-2 controls expression of CREB and
c-Jun during T cell activation
Liu et al., Cancer Res 2009
(Mammary Neoplasms, Experimental) :
Activating transcription factor 2 and
c-Jun mediated
induction of FoxP3 for experimental therapy of mammary tumor in the mouse
Daffis et al., PLoS Pathog 2009
(West Nile Fever) :
However, pharmacological inhibition of NF-kappaB and
ATF-2/c-Jun , the two other known components of the IFN-beta enhanceosome, strongly
reduced IFN-beta gene transcription in the DKO dendritic cells
Fu et al., J Biol Chem 2011
(Carcinoma, Hepatocellular...) :
The increased expression of
c-JUN was
dependent on
ATF2 and on activation of the MEK-ERK and JNK arms of the MAPK signaling pathways
Lu et al., J Dermatol 2013
:
Importantly,
JUN may
regulate activating transcription factor 3 expression to involve cell proliferation process ; STAT1 and STAT3 can inhibit tissue inhibitor of metalloproteinases-3 expression to modulate the cell adhesion molecule pathway ; NF-?B and E2F1 can downregulate cyclin D1, but upregulate proliferating cell nuclear antigen expression to promote the cell cycle pathway
Lindaman et al., Mol Cell Endocrinol 2013
(MAP Kinase Signaling System) :
Phosphorylation of
ATF2 and interaction with NFY
induces c-Jun in the gonadotrope ... Functional
ATF2 is
necessary for both GnRH induction of
c-Jun and FSHß
Sjöblom et al., J Virol 1998
:
In contrast, the
ATF-2/c-Jun heterodimer had only a minor stimulatory effect in the absence of EBNA2 but
induced a strong transactivation of the
LMP1 promoter when coexpressed with this protein
Pober et al., Pathol Biol (Paris) 1998
:
Activation of
c-Jun/ATF-2 involves new
c-Jun synthesis, and more importantly, phosphorylation of the amino terminus of c-Jun by Jun N-terminal kinase (JNK)
Yi et al., J Immunol 1998
(Lymphoma, B-Cell) :
CpG DNA also induces the phosphorylation of
activating transcription factor-2 , c-Jun, and mitogen activated protein kinase ( MAPK) activated protein kinase 2 as well as the
activation of
activator protein-1 (AP-1) DNA binding
Huguier et al., Mol Cell Biol 1998
(Neoplasms, Experimental) :
Experiments were designed to evaluate a possible
role of
ATF2 in oncogenesis in chick embryo fibroblasts ( CEFs ) in the presence or absence of
v-Jun
Biswas et al., EMBO J 1999
(Calcium Signaling) :
The mitochondrial stress resulted in : ( i ) an enhanced expression of the sarcoplasmic reticular ryanodine receptor-1 (RyR-1), hence potentiating the Ca2+ release in response to its modulator, caffeine ; ( ii ) enhanced levels of Ca2+-responsive factors calineurin, calcineurin dependent NFATc ( cytosolic counterpart of activated T-cell-specific nuclear factor ) and
c-Jun N-terminal kinase (JNK) dependent
ATF2 ( activated transcription factor 2); (iii ) reduced levels of transcription factor, NF-kappaB ; and ( iv ) enhanced transcription of cytochrome oxidase Vb (COX Vb) subunit gene