◀ Back to NFKB1
CRK — NFKB1
Text-mined interactions from Literome
Rovin et al., Cytokine 1999
:
Because NF-kappaB is necessary for MCP-1 gene expression, the
effect of
p38 kinase inhibition on IL-1beta induction of
NF-kappaB was measured
Ingram et al., American journal of physiology. Renal physiology 2000
:
Thus strain induces p38 activity and translocation to the nucleus and
p38 dependent increases in nuclear protein binding to
NF-kappaB
Bauer et al., Shock 2000
:
Adherence alone did not activate p38MAPK or NF-kappaB, but primed Mphi for an augmented response to LPS in
activation of
p38 ,
NF-kappaB and in production of TNF-alpha
Tsukagoshi et al., Regul Pept 2001
:
ANP inhibited the IFN-gamma induced
p38 MAP kinase activation, and ANP and SB203580
inhibited NF-kappaB activation
Xu et al., Biochem J 2001
:
Nuclear factor-kappaB
(NF-kappaB) , a previously identified positive regulator of MMP-1 expression induced by fl-coll [ Xu, Zutter, Santoro and Clark ( 1998 ) J. Cell Biol. 140, 709-719 ] was
mediated by fl-coll activated
p38alpha
Ivanov et al., Oncogene 2001
(Melanoma) :
Conversely, activation of IKK attenuates the sensitization of melanoma by TRAF2DeltaN, indicating that
p38 mediated suppression of
NF-kappaB activity is among TRAF2DeltaN effects
Guo et al., J Cell Biochem 2001
:
While it is unclear whether p38beta regulates NF-kappaB transcription activity at other steps, it is apparent that
p38beta does not
affect TNF-alpha induced
NF-kappaB activation at the stage of nuclear translocation
Jijon et al., Am J Physiol Cell Physiol 2002
:
Furthermore, AP-1 and
NF-kappaB DNA binding was not
affected by ERK and
p38 inhibition
Waldhoer et al., J Virol 2002
:
The use of specific inhibitors indicated that the
p38 mitogen activated protein ( MAP ) kinase but not the extracellular signal regulated kinase 1/2-MAP kinase pathway is
involved in M33- and US28 mediated CREB activation but not
NF-kappaB activation
Park et al., Science 2002
(MAP Kinase Signaling System...) :
Because macrophages that are deficient in transcription factor nuclear factor kappaB (NF-kappaB) are also sensitive to activation induced death and p38 is required for expression of certain NF-kappaB target genes,
p38 is probably
essential for synergistic induction of those
NF-kappaB target genes that prevent apoptosis of activated macrophages
Shimada et al., Carcinogenesis 2003
(Prostatic Neoplasms) :
The results suggest that not only p53 induction through
p38/JNK dependent
NFkappaB/AP-1 activation but also JNK dependent Bcl-2 phosphorylation are required for 2-ME induced apoptosis ; moreover, inhibition of these pathways may be involved in androgen mediated resistance to apoptosis
Le Page et al., Biol Chem 2003
(Inflammation) :
In RAW264.7 macrophages the inducers of
NF-kappaB activate the production of reactive oxygen species and three mitogen activated protein kinases ( MAPK ), the extracellular signal regulated kinase ( ERK ), the c-jun N-terminal kinase/stress activated protein kinase ( JNK ), and
p38
Baeza-Raja et al., Mol Biol Cell 2004
:
Activation of
p38 in C2C12 cells induced the activity of NF-kappaB, in a dual way : first, by reducing IkappaBalpha levels and
inducing NF-kappaB-DNA binding activity and, second, by potentiating the transactivating activity of p65-NF-kappaB
Nojek et al., Medicina (B Aires) 2004
:
We determined that : 1 ) the
p38 specific inhibitor
reduces 50 %
NF-kappaB transcriptional activity, even in cells that overexpress distinct TIF2 deletions ; 2 ) there is a physical interaction between TIF2 and p38 and RelA determined through in vitro translated protein binding assays ; 3 ) TIF2 is a p38 substrate ; 4 ) there is a physical interaction between TIF2 and IKK in TNF-alpha 20 ng/ml stimulated or not HEK 293 cell protein extract, and IkappaB only in basal conditions, determined by binding pull down assays
Ueno et al., Cardiovasc Toxicol 2006
(Atherosclerosis) :
Our results indicate that nicotine enhances the expression of ICAM-1 and VCAM-1 on the endothelial cell surface via a second messenger pathway which involves PKC and
p38 MAPK mediated
activation of
NF-kappaB and AP-1, resulting in increased expression of these cellular adhesion molecules
Kim et al., Eur J Pharmacol 2006
:
Cordycepin inhibits lipopolysaccharide induced inflammation by the suppression of
NF-kappaB through Akt and
p38 inhibition in RAW 264.7 macrophage cells
Li et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis...) :
JAK1/TYK2 leads to STAT3 activation, Akt dependent
NF-kappaB activation , and phosphorylation of extracellular signal regulated kinase 1/2 and mitogen activated kinase
p38
Kang et al., Biochem Pharmacol 2008
:
SK-126 enhanced ERK1/2 and
p38 activation following LPS stimulation, but it did not
induce phosphorylation of SAPK/JNK and
NF-kappaB
Zhao et al., J Cardiovasc Pharmacol 2008
:
Our findings suggest that aspirin can decrease inflammatory responses induced by ox-LDL, and the mechanism might be associated with
NF-kappaB activation pathway and
inhibition of
p38 MAPK phosphorylation
Noman et al., Innate Immun 2009
:
Thalidomide prevented the activation of
nuclear factor (NF)-KB by down regulating phosphorylation of inhibitory KB factor ( IKB ), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide
inhibited LPS induced phosphorylation of AKT,
p38 and stress activated protein kinase ( SAPK ) /JNK
Ming et al., BMC cardiovascular disorders 2009
:
Moreover, the inhibitory effect of L-norvaline was not reversed by the NOS inhibitor L-NAME and L-norvaline did not interfere with TNFalpha induced
activation of
NF-kappaB , JNK,
p38mapk , while it inhibited p70s6k ( S6K1 ) activity
Kim et al., Rheumatology (Oxford) 2009
(Osteoarthritis) :
MAP kinases [
p38 , extracellular signal regulated protein kinase ( ERK ) and C-Jun N terminal kinase (JNK) ] and
NF-kappaB activation were evaluated by western blotting and by an electrophoretic mobility shift assay, respectively
Weng et al., J Biomed Sci 2009
(Liver Cirrhosis, Biliary...) :
Arm also suppressed TNF-alpha induced collagen collagen deposition,
NFkappaB activation and MAPK (
p38 , ERK1/2, and JNK ) phosphorylations
Qin et al., J Immunol 2009
(Arthritis, Experimental) :
HMGB1 promotes the phosphorylation of MAPK
p38 and the
activation of
NF-kappaB through RAGE, and then enhances the expression of proinflammatory cytokines
Khan et al., Mol Cell Biochem 2010
(Escherichia coli Infections...) :
In this article, we have shown that EAEC induced activation of mitogen activated protein kinases ( MAPK ) ( ERK-1/2, JNK and
p38MAPK ) in cultured human intestinal epithelial cells ( INT-407 )
leads to the induction of DNA binding activity of
NF-kappaB and AP-1, resulting in IL-8 production
Chen et al., Exp Eye Res 2010
(Dry Eye Syndromes) :
p38 inhibitor suppressed hyperosmoticity induced NF-kappaB activation, indicating that
NF-kappaB activation was
dependent on
p38 activation
Cao et al., Int Immunopharmacol 2010
(Disease Models, Animal...) :
We further observed that MA prevented the LPS induced
nuclear factor-kappa B (NF-kappaB) translocation from the cytoplasm into the nucleus, and
inhibited the LPS induced phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and
p38
Damgaard et al., Discov Med 2011
(Inflammation) :
Recent evidence suggests that cIAP1, cIAP2, and XIAP facilitate ubiquitin dependent signaling activated by these PRRs and mediate
activation of
nuclear factor-kappa B (NF-kappaB) transcription factors as well as the MAP kinases
p38 and JNK
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011
(Carcinoma, Hepatocellular...) :
p38 MAPK inhibitor ( SB203580 ) could significantly inhibit IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially
inhibited NF-kB p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )
Modur et al., J Biol Chem 1996
:
Thus activation of the ERK cascade alone is an incomplete endothelial cell stimulus, and the TNF receptor generates at least two signals : Raf-1 activation, which could be ceramide dependent ; and ceramide independent efficient
NF-kappaB translocation and
activation of
p38 and JNK-1 mitogen activated kinases