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CD4 — IL17D
Text-mined interactions from Literome
Takeda et al., J Immunol 2003
:
Although IL-27 did not directly induce IFN-gamma production by wild-type CD4 ( + ) T cells, IL-12 dependent IFN-gamma production was augmented by
IL-27 stimulation in wild-type naive CD4 ( + ) T cells but was
impaired in WSX-1-deficient naive
CD4 ( + ) T cells
Villarino et al., Int Immunol 2008
(Chronic Disease...) :
In both models of intestinal inflammation, improved clinical outcome was associated with reduced inflammation and profound attenuation of T ( h ) 1 responses and, consistent with these in vivo findings, we confirmed that during in vitro differentiation,
IL-27 directly
promotes CD4 ( + ) T cell IFN-gamma production through effects on Tbet, a key T ( h ) 1 transcription factor
Charlot-Rabiega et al., J Biol Chem 2011
:
IL-27 proliferative effect on naive
CD4 ( + ) T cells is independent of MAPK, but is
dependent on c-Myc and Pim-1 induction by
IL-27 and is associated with induction of cyclin D2, cyclin D3, and CDK4 by IL-27 in a c-Myc and Pim-1 dependent manner
Wojno et al., Trends Immunol 2012
:
This review discusses recent work that has explored the
effect of
IL-27 on
CD4 ( + ) T cell subsets, including T regulatory type 1 (Tr-1) cells, T follicular helper cells ( Tfhs ), and forkhead box P3 (Foxp3) ( + ) T regulatory cells ( Tregs )
Iwasaki et al., Eur J Immunol 2013
:
Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in
IL-27 stimulated
CD4 ( + ) T cells
Gwyer Findlay et al., J Immunol 2013
(Inflammation...) :
Surprisingly, however, the
role of
IL-27 in restricting or shaping effector
CD4 ( + ) T cell chemotactic responses, as a mechanism to reduce T cell dependent tissue inflammation, is unknown ... These data reveal a previously unappreciated
role for
IL-27 in modulating
CD4 ( + ) T cell chemotactic pathways during infection, which is related to its capacity to repress Th1 effector cell development