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FAS — TRAF2
Pathways - manually collected, often from reviews:
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NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
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NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Kosaka et al., Eur J Immunol 1999
:
Nonetheless, a functional link between TRAF2 and IKK activity in B cells is demonstrated by the fact that overexpression of
TRAF2 constitutively
induces IKK activity, NF-kappaB luciferase and
Fas expression
Ivanov et al., Oncogene 2000
(Melanoma) :
Conversely, forced expression of the dominant negative form of
TRAF2 or GCK in late-stage melanoma cells
reduced NF-kappaB activity and decreased
Fas expression, resulting in a lower degree of UV-induced, Fas mediated cell death