◀ Back to HIF1A
ANGPT2 — HIF1A
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ANGPT2
→
HIF1A
(increases, ANGPT2 Activity)
Yamakawa et al., Circ Res 2003*
Evidence: In primary human endothelial cells, hypoxia, desferrioxamine, or infection with Ad2/HIF-1alpha/VP16, an adenoviral vector encoding a constitutively stable hybrid form of HIF-1alpha, increased the mRNA and protein levels of VEGF, angiopoietin-2 (Ang-2), and angiopoietin-4 (Ang-4)
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WikiPathways Photodynamic therapy-induced HIF-1 survival signaling:
ARNT/HIF1A
→
SERPINE1/EDN1/NOS2/PTGS2/ANGPT1/VEGFA/TGFB3/TGFA/EPO/ANGPT2
(activation)
Text-mined interactions from Literome
Richard et al., J Biol Chem 2000
:
More interestingly,
Angiotensin II (Ang II) , thrombin, platelet derived growth factor, and other hormones can also
increase HIF-1alpha in VSMC to levels that are substantially more elevated than the hypoxic treatment
Yamakawa et al., American journal of physiology. Renal physiology 2004
(Adenocarcinoma, Clear Cell...) :
In RPTE cells,
angiopoietin-4 (Ang-4) expression was selectively
induced by hypoxia or by expression of a hybrid form of
HIF-1alpha
Wolf et al., Antioxid Redox Signal 2005
(Anoxia...) :
ANG II induces
HIF-1alpha by a posttranscriptional mechanism suggesting that SM20 down-regulation leads to stabilization of HIF-1
Abaci et al., Am J Physiol Cell Physiol 2010
:
Corresponding upregulation of VEGF,
ANGPT2 , and GLUT-1 was observed in
response to
HIF-1alpha accumulation, whereas upregulation of ANGPT1 was detected only in hESCs and iPSCs