Gene interactions and pathways from curated databases and text-mining

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CDCA3 — PTGS2

Text-mined interactions from Literome

Soma et al., Int J Cancer 2006 (Disease Progression...) : CDCA induced COX-2 in the cell lysate increased the secretion of VEGF into the culture medium
Oshio et al., J Gastroenterol 2008 (Colorectal Neoplasms) : The COX-2 promoter was induced by lithocholic acid (LCA), deoxycholic acid ( DCA ), and chenodeoxycholic acid ( CDCA )
Su et al., Respirology 2013 : CDCA induced significant p38 and c-Jun N-terminal kinase (JNK) phosphorylation, cytosolic phospholipase A2 (cPLA2 ) and cyclooxygenase-2 (COX-2) messenger RNA expression, PGE2 production, TER reduction and decay of JP ( including occludin, zonula occludens-1 ( ZO-1 ) and E-cadherin, in which ZO-1 had maximal change )