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HDAC2 — IL6
Text-mined interactions from Literome
Frost et al., Am J Physiol Endocrinol Metab 2004
:
Optimal
IL-6 synthesis may
require both stress kinase and
histone deacetylase activity
Mantovani et al., Vascul Pharmacol 2006
(Cardiovascular Diseases...) :
CRP and
SAP are produced primarily in the liver in
response to
IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Chokas et al., J Biol Chem 2010
(Hyperoxia) :
Importantly, we show in vivo that Foxp1 and
HDAC2 act cooperatively to
regulate expression of the cytoprotective cytokine
interleukin-6 , which results in increased resistance to hyperoxic lung injury in Foxp1/HDAC2 compound mutant animals
Pietrella et al., Infect Immun 2010
(Inflammation) :
In particular Sap1,
Sap2 , and Sap6 significantly
induced interleukin-1ß (IL-1ß), tumor necrosis factor alpha ( TNF-a ), and
IL-6 production
Garlanda et al., Curr Pharm Des 2011
(Atherosclerosis...) :
CRP and
SAP are produced primarily in the liver in
response to
IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Rehni et al., Naunyn Schmiedebergs Arch Pharmacol 2012
(Opioid-Related Disorders...) :
The present study has been designed to investigate the effect of selective inhibitors of
histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al ( Ac-DEVD-CHO ), a selective
interleukin-1ß converting enzyme
inhibitor , on the development of naloxone induced opioid withdrawal syndrome both in vitro and in vivo and the effect of histone deacetylase inhibition on histone H3 acetylation in brain
Vitoriano-Souza et al., PloS one 2012
:
With regard to cytokines, the
SAP led to production of interleukin (IL)-2,
IL-6 , and IL-4
Liu et al., Journal of inflammation (London, England) 2013
:
In addition,
HDAC inhibitors significantly
inhibited poly ( I:C ) -induced
IL-6 production in both of the epithelial cells
Ku et al., Cytokine 1993
(Carcinoma, Hepatocellular...) :
By contrast, gene expression of the major APR of the mouse,
serum amyloid P-component (SAP) , a structural homologue of CRP, increased in
response to either IL-1 or
IL-6 under the same conditions