Gene interactions and pathways from curated databases and text-mining

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ACE — IL6

Text-mined interactions from Literome

Jeron et al., Immunobiology 2002 (Hypertrophy, Left Ventricular) : Chronic immunosuppressive therapy normalized systemic IL-6 levels, but failed to reduce cardiac IL-6 expression and the progression of LVH, while ACE inhibition is sufficient to modify LVH and thereby normalises myocardial IL-6 expression
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE) , matrix metalloproteinase (MMP)-1, -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF), monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6 , though the mechanisms were not clear
Fleming et al., Pediatr Crit Care Med 2011 (Heart Defects, Congenital...) : Angiotensin converting enzyme inhibition attenuates the increase in postoperative plasminogen activator inhibitor-1 but enhances the interleukin-6 response in children undergoing cardiopulmonary bypass
Goto et al., Ann Rheum Dis 1990 (Arthritis, Rheumatoid) : Angiotensin converting enzyme activity was raised in most ( 29/32 ) patients with RA and interleukin 1 activity ( most of which was interleukin 1 beta ) was enhanced in 11/32 patients with RA, while monocytes from only two patients with osteoarthritis, but from none of the controls, secreted a small amount of ACE alone in the culture condition
Sriramula et al., Cardiovasc Res 2011 (Disease Models, Animal...) : Additionally, ACE2 overexpression in the PVN attenuated the Ang II-induced increase in the expression of the pro-inflammatory cytokines tumour necrosis factor-a, interleukin (IL)-1ß and IL-6 in the PVN