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ACE — IL6
Text-mined interactions from Literome
Jeron et al., Immunobiology 2002
(Hypertrophy, Left Ventricular) :
Chronic immunosuppressive therapy normalized systemic IL-6 levels, but failed to reduce cardiac IL-6 expression and the progression of LVH, while
ACE inhibition is
sufficient to modify LVH and thereby normalises myocardial
IL-6 expression
Imafuku et al., Clin Chim Acta 2002
:
We also found a definite effects on copper,
angiotensin converting enzyme (ACE) , matrix metalloproteinase (MMP)-1, -3 and -9, tissue
inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF), monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and
IL-6 , though the mechanisms were not clear
Fleming et al., Pediatr Crit Care Med 2011
(Heart Defects, Congenital...) :
Angiotensin converting enzyme inhibition attenuates the increase in postoperative plasminogen activator inhibitor-1 but
enhances the
interleukin-6 response in children undergoing cardiopulmonary bypass
Goto et al., Ann Rheum Dis 1990
(Arthritis, Rheumatoid) :
Angiotensin converting enzyme activity was raised in most ( 29/32 ) patients with RA and
interleukin 1 activity ( most of which was interleukin 1 beta ) was
enhanced in 11/32 patients with RA, while monocytes from only two patients with osteoarthritis, but from none of the controls, secreted a small amount of
ACE alone in the culture condition
Sriramula et al., Cardiovasc Res 2011
(Disease Models, Animal...) :
Additionally,
ACE2 overexpression in the PVN
attenuated the Ang II-induced increase in the expression of the pro-inflammatory cytokines tumour necrosis factor-a, interleukin (IL)-1ß and
IL-6 in the PVN