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EGF — GJA1

Text-mined interactions from Literome

Ueki et al., Neurosci Lett 2001 : We have further shown that the decrease is associated with the receptor tyrosine kinase pathway and the MEK inhibitor prevents EGF stimulated down-regulation of Cx43 expression
Bolamba et al., Biol Reprod 2002 : EGF increased expression of Cx43 protein in secondary preantral follicles in a dose dependent manner, which suggests that EGF or similar growth factor molecules may modulate early folliculogenesis by stimulating expression of Cx43 gap junctions
Kennedy et al., Mol Reprod Dev 2003 : Cx43 expression and regulation by epidermal growth factor (EGF) were characterized in immature rabbit granulosa cells
Leykauf et al., Cell Tissue Res 2003 : EGF or stress treatment of the cells results in a rapid increase in the phosphorylated forms of Cx43 as revealed by immunoblotting
Leithe et al., J Cell Sci 2004 (MAP Kinase Signaling System) : These EGF induced modifications of Cx43 were counteracted by the MEK1 inhibitor PD98059, indicating that the effects were mediated by the mitogen activated protein kinase pathway ... Taken together, these data provide the first evidence that EGF induced phosphorylation of Cx43 induces binding of ubiquitin and targets Cx43 for internalization and degradation in a proteasome dependent manner
Park et al., Cell Prolif 2008 (Calcium Signaling) : Therefore, this study has examined the effect of epidermal growth factor (EGF) on Cx43 and its relationship to proliferation of mouse embryonic stem cells ... The results showed that EGF increased the level of Cx43 phosphorylation in a time- ( > or =5 min ) and dose- ( > or =10 ng/mL ) dependent manner ... Indeed, EGF induced increase in phospho-Cx43 level was significantly blocked by either AG 1478 or herbimycin A ( tyrosine kinase inhibitors ) ... Moreover, pre-treatment with BAPTA-AM ( an intracellular Ca ( 2+ ) chelator ), EGTA ( an extracellular Ca ( 2+ ) chelator ), bisindolylmaleimide I or staurosporine ( PKC inhibitors ) inhibited the EGF induced phosphorylation of Cx43 ... EGF induced phosphorylation of Cx43 , which was mediated by the Ca ( 2+ ) /PKC, p44/42 and p38 MAPKs pathways, partially contributed to regulation of mouse embryonic stem cell proliferation
Oh et al., Cell adhesion and communication 1993 : Epidermal growth factor (EGF) stimulated the phosphorylation of connexin43 (Cx43) in WB cells as evidenced by the formation of multiple immunoreactive Cx43 proteins of higher molecular mass which were abolished by treatment with alkaline phosphatase
Kanemitsu et al., Mol Biol Cell 1993 : We previously reported that epidermal growth factor (EGF) induced the disruption of gap junctional communication ( gjc ) and serine phosphorylation of connexin43 (Cx43) in T51B rat liver epithelial cells ... EGF in the presence or absence of chronic TPA treatment stimulated marked increases in Cx43 phosphorylation on numerous sites as determined by two-dimensional tryptic phosphopeptide mapping ... Therefore, EGF induced disruption of gjc and phosphorylation of Cx43 may be mediated in part by MAP kinase in vivo
Husøy et al., Carcinogenesis 1993 : 12-O-Tetradecanoylphorbol-13-acetate ( TPA ) is able to induce the phosphorylation of both cx43 and the EGF receptor, concomitantly with a decrease in GJIC and [ 125I ] -EGF binding
Vikhamar et al., Cell adhesion and communication 1998 : In the present study it is shown that 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and EGF induce similar phosphorylation pattern of the gap junction protein connexin43 (Cx43) in K7 cells, although their effects on GJIC are opposite