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BCAR1 — RAC1
Pathways - manually collected, often from reviews:
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BioCarta links between pyk2 and map kinases:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
RAC1
(modification, activates)
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BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
RAC1
(modification, activates)
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NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
RAC1/GDP complex (RAC1)
→
p130 CAS/CRK/DOCK1 complex (BCAR1-CRK-DOCK1)
(modification, collaborate)
Kjøller et al., J Cell Biol 2001, Tushir et al., EMBO J 2007, Wei et al., Nat Med 2008, Smith et al., J Cell Biol 2008
Evidence: mutant phenotype
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NCI Pathway Database Signaling events mediated by focal adhesion kinase:
RAC1/GDP complex (RAC1)
→
FAK/Src-Yes-Fyn/p130 CAS/CRK/DOCK1/ELMO1 complex (PTK2-YES1_SRC_FYN-BCAR1-CRK-DOCK1-ELMO1)
(modification, collaborate)
Cho et al., J Cell Biol 2002, Hsia et al., J Cell Biol 2003, Sharma et al., BMC cell biology 2008, Kiyokawa et al., Genes Dev 1998, Dolfi et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Alpha9 beta1 integrin signaling events:
RAC1/GDP complex (RAC1)
→
p130 Cas (BCAR1)
(modification, collaborate)
Gupta et al., J Cell Sci 2009*
Evidence: mutant phenotype
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NCI Pathway Database Netrin-mediated signaling events:
RAC1/GDP complex (RAC1)
→
netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1)
(modification, collaborate)
Liu et al., J Neurosci 2007
Evidence: mutant phenotype
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NCI Pathway Database Netrin-mediated signaling events:
netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Liu et al., J Neurosci 2007
Evidence: mutant phenotype
-
NCI Pathway Database RAC1 signaling pathway:
RAC1/GTP complex (RAC1)
→
p130 CAS/CRK complex (BCAR1-CRK)
(modification, activates)
Girardin et al., EMBO J 2001*
Evidence: assay, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
RAC1/GTP complex (RAC1)
→
p130 Cas (BCAR1)
(modification, activates)
Girardin et al., EMBO J 2001*
Evidence: assay, physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
RAC1/GDP complex (RAC1)
→
p130CAS/Crk/Dock1 complex (BCAR1-CRK-DOCK1)
(modification, collaborate)
Hsia et al., Mol Cell Biol 2005
Evidence: mutant phenotype
-
Reactome Reaction:
BCAR1
→
RAC1
(reaction)
Brugnera et al., Nat Cell Biol 2002
Text-mined interactions from Literome
Hsia et al., J Cell Biol 2003
(Neoplasm Invasiveness...) :
Cell invasion was linked to transient FAK accumulation at lamellipodia, formation of a
FAK-Src-p130Cas-Dock180 signaling complex, elevated
Rac and c-Jun NH2-terminal kinase
activation , and increased matrix metalloproteinase expression and activity
Smith et al., J Cell Biol 2008
(Neoplasm Invasiveness) :
We show that uPAR cooperates with integrin complexes containing beta ( 3 ) integrin to drive formation of the
p130Cas-CrkII signaling complex and
activation of
Rac , resulting in a Rac-driven elongated-mesenchymal morphology, cell motility, and invasion