Besch et al., Cell Death Differ 2007
(Melanoma...) :
uPAR inhibition induced the expression of the tumor suppressor p53 and of its downstream target gene p21
Shetty et al., Mol Cell Biol 2007
(Lung Neoplasms) :
Expression of p53 protein in p53 ( -/- ) cells suppressed basal and urokinase ( uPA ) -induced cell surface uPAR protein and increased uPAR mRNA degradation ... Inhibition of p53 by RNA silencing in Beas2B human airway epithelial cells conversely increased basal as well as uPA mediated uPAR expression and stabilized uPAR mRNA
Bhandary et al., Am J Physiol Lung Cell Mol Physiol 2012
(Acute Lung Injury...) :
Thus p53 is increased and inhibits expression of uPA and uPAR while increasing PAI-1, changes that promote ATII cell apoptosis in mice with BLM induced ALI