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PI3 — SLC9A3
Text-mined interactions from Literome
Donowitz et al., Ann N Y Acad Sci 2000
:
PI 3-kinase was also
involved in FGF stimulation of
NHE3 expressed in fibroblasts
Lee-Kwon et al., J Biol Chem 2001
:
Previous studies have indicated that
PI 3-kinase is necessary for basal Na(+)/H(+) exchanger 3 ( NHE3 ) transport and for fibroblast growth factor
stimulated NHE3 activity in PS120 fibroblasts ... However, it is not known whether activation of
PI 3-kinase is
sufficient to stimulate
NHE3 activity or whether Akt is involved in this PI 3-kinase effect ... We used an adenoviral infection system to test the possibility that activation of
PI 3-kinase or Akt alone is
sufficient to stimulate
NHE3 activity ... The magnitudes of
stimulation of
NHE3 by constitutively active
PI 3-kinase , PI 3-kinase peptide, and constitutively active Akt were similar to each other ... These results demonstrate that activation of
PI 3-kinase or Akt is
sufficient to stimulate
NHE3 transport activity in PS120/NHE3 cells
He et al., Mol Biol Cell 2011
:
Activation of SGK3 and
NHE3 by Dex was
dependent on
phosphoinositide 3-kinase (PI3K) and phosphoinositide dependent kinase 1 ( PDK1 ), and Dex induced translocation of PDK1 to endosomes