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CPOX — GPI

Text-mined interactions from Literome

Weaver et al., Free Radic Biol Med 2001 : Furthermore, inhibition of COX and addition of PGH ( 2 ) to Se-deficient or Se-supplemented BAEC still resulted in lower PGI ( 2 ) formation by Se-deficient cells
Tang et al., Eur J Pharmacol 2008 : Cyclooxigenase(COX) inhibitor, indomethacin, significantly reduced elevated PGI ( 2 ) level by both PDR and SNP in RAEC medium
Selg et al., Prostaglandins Other Lipid Mediat 2009 : In the isolated guinea-pig trachea, neither PGD ( 2 ) nor U-46619 actively released PGE ( 2 ), but continuous production of PGE ( 2 ) and PGI ( 2 ) was established, and the response to PGD ( 2 ) was enhanced also in the trachea by COX inhibition
Amaya et al., Pain 2009 (Disease Models, Animal...) : The PGI also induced a prominent increase in IL-1beta and TNF-alpha levels in the DRG and of cyclooxygenase-2 (COX-2) expression in neurons and satellite cells
Deacon et al., J Biol Chem 2010 (Vascular Diseases) : Amphiregulin, follistatin, and inhibin-beta-A and epiregulin were activated by an autocrine loop involving cPLA2, arachidonic acid release, COX-2 dependent PGI ( 2 ) synthesis, and IP receptor linked elevation of cAMP leading to CRE transcription activation
Liu et al., Exp Physiol 2012 : This study was to determine whether the endothelium of mouse major arteries produces prostacyclin ( PGI ( 2 ) ) and, if so, to determine how PGI ( 2 ) affects vasomotor reactivity and whether cyclo-oxygenase-1 (COX-1) contributes to PGI ( 2 ) synthesis
Przygodzki et al., Eur J Pharmacol 2013 (Diabetes Mellitus) : However, COX-2 activity significantly contributed to PGI ( 2 ) synthesis in healthy rats, with prostacyclin secretion being two-fold decreased by NS-398
Sakata et al., Thromb Res 2013 (Carotid Artery Thrombosis...) : Aspirin inhibits both the cyclooxygenase (COX)-1 dependent production of thromboxane A2 ( TXA2 ) in platelets and COX-2 dependent production of anti-aggregatory prostaglandin I2 (PGI2) in vessel walls, resulting in `` aspirin dilemma. ''
Tetsuka et al., Proc Natl Acad Sci U S A 1994 : These data suggest that ( i ) endogenous PGE2 downregulates iNOS induction, ( ii ) this inhibitory effect of PGE2 on iNOS induction is not mediated by activation of adenylate cyclase, and ( iii ) exogenous PGI2 stimulates COX induction possibly by activation of adenylate cyclase
Pang et al., Biochem Pharmacol 1997 : After a 2-hr pretreatment before adding endotoxin, PGE2, PGI2 , forskolin, IBMX ( isobutylmethylxanthine, a cyclicAMP/cyclicGMP phosphodiesterase inhibitor ), 8-bromo cyclicAMP, and arachidonic acid itself all inhibited the expression of both iNOS and COX-2 ( as shown by Western blotting ) and reduced NO release and COX activity, whereas PGF2 alpha and 8-bromo cyclic GMP were only weakly effective