Gene interactions and pathways from curated databases and text-mining

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HAVCR2 — TNF

Text-mined interactions from Literome

Hastings et al., Eur J Immunol 2009 : In addition, human CD4 ( + ) T cells secreted elevated levels of IFN-gamma, IL-17, IL-2, and IL-6, but not IL-10, IL-4, or TNF-alpha , when stimulated with anti-CD3/anti-CD28 in the presence of TIM-3-specific , putative antagonistic antibodies
Qiu et al., PLoS Pathog 2012 (Tuberculosis) : Mechanistic experiments showed that siRNA silencing of Tim-3 or soluble Tim-3 treatment interfering with membrane Tim-3-ligand interaction reduced de novo production of IFN-? and TNF-a by Tim-3 expressing T cells