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CD40 — MMP3
Text-mined interactions from Literome
Gotoh et al., J Rheumatol 2004
(Arthritis, Rheumatoid...) :
CD40-CD154 interaction
augments the expression of inflammatory cytokines and
MMP in chondrocytes and contributes to an intrinsic process of cartilage degradation in RA
Oviedo-Orta et al., Immunology 2008
:
Finally, we investigated whether
CD40-CD40 ligand (CD40L) interactions were
involved in T-cell stimulated
MMP secretion from macrophages
Wassenaar et al., Clin Exp Immunol 1999
:
We show that
CD40 ligation on gingival fibroblasts
resulted in a decrease of their MMP-1 and
MMP-3 production, while MMP-2 and TIMP-1 production were unaffected as determined by Western blot ... This down-regulatory
effect of
CD40 engagement on MMP-1 and
MMP-3 production by gingival fibroblasts was also present when MMP production was up-regulated by IL-1beta and TNF-alpha or down-regulated by IFN-gamma