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CD40 — VCAM1
Text-mined interactions from Literome
Jollow et al., Transplantation 1999
:
CD40-CD40L interactions
induced the expression of the adhesion molecules
VCAM-1 and E-selectin and the costimulatory molecule CD80 but not CD86 ( B7-2 ) on the MECs
Propst et al., J Immunol 2000
(Inflammation) :
Cross linking epithelial
CD40 had no effect on expression of the adhesion molecule
VCAM-1
Rushworth et al., Transplantation 2002
:
We have previously shown that binding of human CD154 expressed on the Jurkat D1.1 cell line to porcine
CD40 on pig aortic endothelial cells ( PAECs ) can
lead to up-regulation of
vascular cell adhesion molecule (VCAM)-1 and MHC class II
Longo et al., Circulation 2003
:
In human coronary artery ECs ( HCAECs ), adenovirus mediated overexpression of A20 blocks physiological,
CD40 induced
activation of NF-kappaB, upstream of IkappaBalpha degradation ( Western blot ) and subsequently upregulation of ICAM-1,
VCAM-1 , and E-selectin ( flow cytometry )
Yellin et al., J Leukoc Biol 1995
(Arthritis, Rheumatoid...) :
Ligation of
CD40 on fibroblasts
induces CD54 ( ICAM-1 ) and
CD106 ( VCAM-1 ) up-regulation and IL-6 production and proliferation ... CD40 expression on fibroblasts is functionally significant because
CD40L-CD40 interactions
induce SM fibroblast CD54 ( intercellular adhesion molecule-1 ) and
CD106 ( vascular cell adhesion molecule-1 ) up-regulation
Karmann et al., J Exp Med 1996
:
We have reported previously that activation of human umbilical vein endothelial cells ( HUVECs ) through
CD40 , using a recombinant soluble form of trimerized CD40 ligand,
leads to induction of E-selectin,
vascular cell adhesion molecule-1 ( VCAM-1 ), and intercellular adhesion molecule-1 ( ICAM-1 )