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ERF — TP53
Text-mined interactions from Literome
Taylor et al., J Biol Chem 2001
:
The R box confers p53 dependent repression on heterologous promoters and binds to
p130/E2F4 in
response to overexpression of
p53
Wang et al., Pharmazie 2010
(Brain Neoplasms...) :
It suppressed drug related Cdk1 activity with a less elevation of regulator proteins such as cyclin B1, Cdk7 and reduced caspase activation and PARP cleavage compared to the efficiency observed in normoxic condition, which were significantly relative with hypoxia-driven inhibition of
p53 and
p-ERK1/2 activation
Park et al., Mol Carcinog 2012
(Colonic Neoplasms...) :
HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced
p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and
increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt,
P-ERK1/2 , P-p38, and P-SAPK/JNK