Gene interactions and pathways from curated databases and text-mining

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IGFBP3 — IRS1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: IRS1 → IGFBP3 (decreases)
    Evidence: exogenous IGFPB3 inhibits IGF1R activation and blocks phosphorylation of IRS1 in MCF-7 cells