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INS — UTP18

Text-mined interactions from Literome

Verspohl et al., Can J Physiol Pharmacol 2002 (Insulinoma...) : UTP increased insulin release ( EC50 approximately/= 2 microM ) very weakly, indicating that a P2U receptor ( P2X3 or possibly a P2Y2 or P2Y4 ) are not likely to be involved
Haugaard et al., Proc Natl Acad Sci U S A 1977 : Insulin significantly increased the synthesis of UTP from extracellular uridine
Sipma et al., Br J Pharmacol 1995 : Regulation of histamine- and UTP induced increases in Ins ( 1,4,5 ) P3, Ins ( 1,3,4,5 ) P4 and Ca2+ by cyclic AMP in DDT1 MF-2 cells
Purkiss et al., Br J Pharmacol 1994 (Second Messenger Systems) : 5. The Ins ( 1,4,5 ) P3 response to UTP was attenuated to 25 % of control by pretreatment of BAE cells with pertussis toxin
Henning et al., Br J Pharmacol 1993 : ATP- and UTP induced Ins ( 1,4,5 ) P3 formation showed cross-desensitization, whereas cross-desensitization was absent in responses elicited by one of the nucleotides and bradykinin
Wilkinson et al., Eur J Pharmacol 1997 : SRIF and UTP caused sustained increases in Ins ( 1,4,5 ) P3 but the SRIF maximum was about 30 % of that to UTP ... UTP induced increases in [ Ca2+ ] i and Ins ( 1,4,5 ) P3 were attenuated in the absence of [ Ca2+ ] e