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FGF21 — FGF4
Text-mined interactions from Literome
Kurosu et al., J Biol Chem 2007
:
Accordingly, FGF19, but not
FGF21 ,
activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Kharitonenkov et al., J Cell Physiol 2008
:
Interestingly,
FGF-21 mediated effects are heparin independent suggesting that betaKlotho plays a role in
FGF-21 activity similar to the one played by heparin in the signaling of conventional FGFs
Blagovic et al., PloS one 2011
:
Then we induce
FGF4 signaling in minimal chemically defined medium ( N2B27 ) and
inhibit FGF signaling in fully supplemented differentiation medium with cell secreted factors to determine that the non-FGF cell secreted factors are required to promote growth of differentiating mESCs
Lü et al., Chin Med J (Engl) 2010
(Coronary Artery Disease) :
Furthermore,
FGF21 levels increased by 200 µmol/L bezafibrate could reduce CMECs apoptosis, and
inhibit FGF21 expression by shRNA induced apoptosis ( P < 0.05 )
Adams et al., PloS one 2012
:
The scaffold protein ßklotho ( KLB ) has previously been demonstrated in vitro to function as a co-factor permitting
FGF21 mediated
FGF receptor activation