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CSF1 — RAC1

Text-mined interactions from Literome

Fukuda et al., J Bone Miner Res 2005 (Bone Resorption) : Rac1 is critically involved in M-CSF receptor signaling and mediates survival signaling primarily through PI3K/Akt pathways ... M-CSF rapidly activated Rac1 , and the prosurvival effect of M-CSF for OCLs was abrogated by Rac1 ( DN ) overexpression ... Small guanosine triphosphatase ( GTPase ) Rac1 is critically involved in M-CSF receptor signaling and mediates survival signaling of osteoclasts primarily by modulating PI3K/Akt pathways
Kim et al., J Clin Invest 2006 (Bone Resorption) : DEX specifically arrested M-CSF activation of RhoA, Rac , and Vav3, each of which regulate the osteoclast cytoskeleton
Sakai et al., Bone 2006 : CSF-1 induced the association of Vav and Rac and increased Rac 's GTPase activity ... CSF-1 also induced rapid translocation of Rac to the periphery of spreading neonatal rat osteoclasts where it co-localized primarily with Vav3 and to a lesser extent with Vav1 ... Wortmannin, an inhibitor of PI3-K, blocked CSF-1 induced Rac translocation and prevented CSF-1 induced spreading and actin reorganization in osteoclasts
Yu et al., J Bone Miner Res 2007 : We conclude that BCA3 regulates CSF-1 dependent Rac activation
Kim et al., Ann N Y Acad Sci 2007 : Dexamethasone specifically arrests M-CSF activation of RhoA, Rac , and Vav3, each of which regulate the osteoclast cytoskeleton
Welliver et al., J Cell Sci 2011 : Consistent with a role for these actin-rich structures in signal amplification, microscopic measures of Rac1 activity determined that disruption of actin polymerization by latrunculin B inhibited ruffling and the localized activation of Rac1 in response to M-CSF