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KDR — RAC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: KDR → RAC1 (increases, RAC1 Activity)
  Evidence: Overexpression of dominant negative N17Rac1 significantly inhibits VEGF-induced ROS production that is involved in VEGFR2 activation, EC migration, and proliferation (100).
• Reactome Reaction: KDR → RAC1 (reaction) Brugnera et al., Nat Cell Biol 2002

Text-mined interactions from Literome

Gavard et al., Nat Cell Biol 2006 : This process is initiated by the activation of the small GTPase Rac by VEGFR-2 through the Src dependent phosphorylation of Vav2, a guanine nucleotide-exchange factor
Garrett et al., Exp Cell Res 2007 : We have found that VEGF stimulates biphasic activation of Rac1 and for these studies we focused on the peak of activation that occurs at 30 min. Inhibition of VEGFR-2 signaling blocks VEGF induced Rac1 activation
Meissner et al., Exp Dermatol 2009 : The inhibitory effects of dominant negative Rac1 on the transcriptional activity of the VEGFR2 promoter localized to an element between -77 and -60 that contains an Sp1 transcription factor binding site