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MSN — RAC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 185 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 177 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 203 proteins (association, cross-linking study) Byron et al., Proteomics 2012

Text-mined interactions from Literome

Jeon et al., J Biol Chem 2005 : Chloride conductance is required for the protein kinase A and Rac1 dependent phosphorylation of moesin at Thr-558 by KCl in PC12 cells ... Moesin phosphorylation at Thr-558 was increased after 2 min of KCl treatment, peaked at 5 min, and returned to the basal level by 60 min. KCl also activated Rac1 , but not RhoA, in PC12 cells, and KCl induced moesin phosphorylation was suppressed in dominant negative Rac1 ( N17 Rac1 ) -expressed cells ... These results suggest that the phosphorylation of moesin at Thr-558 in PC12 cells by KCl treatment is PKA- and Rac1 dependent and that KCl induced chloride conductance is involved in the activation of this signaling system
Rossy et al., Exp Cell Res 2007 (Carcinoma 256, Walker) : We further show that endogenous ezrin and moesin are phosphorylated and that activities of PI-3 kinase, Rho and Rac , but not of Rho-kinase, are required for this C-terminal phosphorylation
Jeon et al., Neurochem Int 2010 : NGF induced moesin phosphorylation is mediated by the PI3K, Rac1 and Akt and required for neurite formation in PC12 cells
Shaw et al., Mol Biol Cell 1998 : An activated allele of RhoA, but not Rac or CDC42Hs, was sufficient to induce apical membrane/actin protrusions and localize radixin or moesin into these structures in both Rat1 and NIH3T3 cells