Gene interactions and pathways from curated databases and text-mining

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CXCR4 — EGF

Text-mined interactions from Literome

Porcile et al., Exp Cell Res 2005 (Carcinoma...) : Our results further indicate that CXCR4 activation induces EGF receptor (EGFR) phosphorylation that in turn was linked to the downstream intracellular kinases activation, ERK1/2 and Akt
Guo et al., Colloids Surf B Biointerfaces 2007 (Neoplasm Metastasis...) : In this research, the result first showed that epidermis growth factor (EGF) enhanced the expression of CXCR4 and the migration of ovarian cancer cells, moreover, both stromal cell derived factor-1alpha ( SDF-1alpha ) and EGF induced high matrix metallopeptidase 9 (MMP9) expressions
Prasad et al., Int J Oncol 2009 (Breast Neoplasms) : These results demonstrate a positive role of SHIP2 in EGF induced Akt activation, CXCR4 expression, and cell migration in breast cancer cells ... These results demonstrate a positive role of SHIP2 in EGF induced Akt activation, CXCR4 expression, and cell migration in breast cancer cells
Al Zobair et al., Oncol Rep 2013 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, we showed that EGF enhanced the expression of CXCR4 in NSCLC cells through the PI-3K pathway, and treatment of NSCLC cells with EGFR phosphorylation inhibitor, AG1478, resulted in downregulation of the expression of CXCR4