Chang et al., Prostaglandins Leukot Essent Fatty Acids 2005
:
To clarify the mechanism of this modulatory influence of 2PTS on the aggregation of platelets, we investigated the effects of 2PTS on cyclooxygenase (COX) activity and the reduced glutathione ( GSH ) concentration in canine platelets ... Platelet COX activity was inhibited by 2PTS in a dose dependent manner up to 0.1 mM, but tended to return to the control level at 1 mM
Liu et al., FEBS Lett 2008
(Shock, Septic) :
In the present study, we found that PTS2 dose-dependently inhibited the LPS induced up-regulation of nitric oxide synthase ( iNOS ) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells