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FOXO3 — PPARGC1A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
PPARGC1A
—
FOXO3
(interaction, mapped from bind kegg_pathways)
-
STRING interaction:
FOXO3
—
PPARGC1A
(interaction, mapped from bind kegg_pathways)
Text-mined interactions from Literome
Sandri et al., Proc Natl Acad Sci U S A 2006
(Muscular Atrophy) :
Transfection of
PGC-1alpha into adult fibers
reduced the capacity of
FoxO3 to cause fiber atrophy and to bind to and transcribe from the atrogin-1 promoter
Olmos et al., J Biol Chem 2009
:
Importantly,
Foxo3a activity
requires the transcriptional co-activator
PGC-1alpha , because it is severely curtailed in PGC-1alpha-deficient endothelial cells