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FASLG — IFNG

Text-mined interactions from Literome

Arnold et al., J Immunol 1999 : Stimulation of the cells with IL-6, IL-10, IL-12, TGF-beta1, and GM-CSF did not modulate the constitutive FasL expression, but IFN-gamma mediated FasL up-regulation was significantly diminished by IL-10 and TGF-beta1, respectively
Khar et al., J Interferon Cytokine Res 1999 (Ascites) : In the present study, we showed that Fas-L expression on AK-5 cells is regulated by interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), as injection of antibodies against IFN-gamma downregulated the expression of Fas-L by tumor cells as determined by immunostaining and Northern hybridizations
Naujokat et al., Biochem Biophys Res Commun 1999 (Adenocarcinoma) : Tumor necrosis factor-alpha and interferon-gamma induce expression of functional Fas ligand on HT29 and MCF7 adenocarcinoma cells ... These results demonstrate that TNF-alpha and IFN-gamma induce expression of functional FasL in adenocarcinoma cells which thereby can kill T lymphocytes by the FasL/Fas pathway
Blüher et al., Eur J Endocrinol 1999 (Thyroiditis, Autoimmune) : However, in contrast to results of recent in vitro studies, in the BB/W rat Fas/FasL expression is not regulated by IL-2, -4, -6, -10, -12, interferon gamma , and tumor necrosis factor alpha
Müschen et al., Immunology 2000 (Breast Neoplasms) : In four breast cancer cell lines, CD95L expression was increased by interferon-gamma (IFN-gamma) , which resulted in higher levels of CD95L-specific apoptosis in co-cultured Jurkat T cells
Badie et al., Exp Neurol 2000 (Glioma) : Flow cytometry was used to quantify the IFN-gamma mediated apoptotic response and Fas and Fas ligand (FasL) expression in two well characterized murine microglia cell lines ( BV-2 and N9 ) ... These findings suggest that in addition to its role as a microglia activator, IFN-gamma may also induce apoptosis of microglia, possibly through simultaneous upregulation of Fas and FasL
Rescigno et al., J Exp Med 2000 (Inflammation) : Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction : a new role for Fas ligand in inflammatory responses
van der Vliet HJ et al., J Immunol Methods 2001 : The expanded Valpha24 ( + ) Vbeta11 ( + ) -T cells expressed the cytotoxic molecule granzyme B, showed negligible expression of Fas ligand and could be induced to express high levels of interferon-gamma , while retaining the capacity to produce IL-4
Wigginton et al., J Clin Invest 2001 (Carcinoma, Renal Cell...) : The IL-12/IL-2 combination synergistically enhances cell surface FasL expression on CD8 ( + ) T lymphocytes in vitro and induces Fas and FasL expression within tumors via an IFN-gamma dependent mechanism in vivo
Abu-Helu et al., J Autoimmun 2001 (Sjogren's Syndrome) : Dexamethasone inhibited the upregulation of Fas and FasL by IFN-gamma and the induction of SGEC apoptosis and detachment by anti-Fas mAb or IFN-gamma
Ishihara et al., Helicobacter 2001 (Helicobacter Infections) : H. pylori antigen and IFN-gamma induced Fas-L mRNA expression in both CD4+ and CD8+ T cells
Hall et al., Gene Ther 2002 (Prostatic Neoplasms) : After demonstrating that Ad.HSV-tk/GCV and Ad.mIL-12 induced IFN-gamma independently up-regulated expression of FasL and Fas, respectively, studies examined tumor cell mediated death through Fas/FasL induced apoptosis as a mechanism of primary tumor growth suppression
Nishikawa et al., Parasite Immunol 2002 : FasL expression was clearly induced by N. caninum-infection and IFN-gamma treatment compared to the T. gondii infected cells and the uninfected control with or without IFN-gamma treatment
Sobek et al., Eur J Immunol 2002 (Lymphocytic Choriomeningitis) : The fact that antibodies to IFN-gamma also inhibit AgICD suggests that the perforin plus granzyme independent and FaSL and/or TNF-alpha facilitated process of AgICD of T effector cells is tightly regulated by endogenous IFN-gamma
Bonetti et al., Glia 2003 (Neuroma, Acoustic...) : T-cell cytotoxicity of human Schwann cells : TNFalpha promotes fasL mediated apoptosis and IFN gamma perforin mediated lysis
De Rose et al., J Leukoc Biol 2004 (Asthma...) : We investigated the effect of recombinant IFN-gamma on proliferation, Fas/Fas ligand (FasL) expression, and apoptosis in allergen stimulated peripheral blood mononuclear cells obtained from atopic, asthmatic patients and nonatopic, control subjects ... IFN-gamma induced an increase in the expression of Fas and FasL by allergen stimulated CD4+ T cells from asthmatic patients and caused the apoptosis of these cells
Puliaev et al., J Immunol 2004 (Acute Disease...) : Thus, both IFN-gamma dependent induction of Fas/FasL and IFN-gamma independent induction of perforin contribute to CTL mediated elimination of host B cells in AGVHD
Chen et al., Endocrinology 2005 : Soluble recombinant Fas ligand ( rFasL ), at 100 ng/ml, significantly decreased cell viability, as measured by 3- ( 4,5-dimethylthiazol-2-yl ) -5- ( 3-carboxymethoxyphenyl ) -2- ( 4-sulfophenyl ) -2H-tetrazolium, inner salt ( MTS ) assay, in the presence of 200 U/ml interferon-gamma , whereas the concurrent addition of a caspase inhibitor, Z-VAD-FMK, at 20 microm, significantly inhibited rFasL induced cytotoxicity
McCullough et al., Int J Exp Pathol 2007 : For the first time in primary hepatocytes, we show that IFNgamma mediated apoptotic signalling requires the cell surface interaction of CD95 and its ligand, and we demonstrate that IFNgamma induces soluble CD95 ligand release from hepatocyte monolayers
Boselli et al., Eur J Immunol 2007 (Mycobacterium Infections) : IFN-gamma regulates Fas ligand expression in human CD4+ T lymphocytes and controls their anti-mycobacterial cytotoxic functions
Zhu et al., Transplant Proc 2008 : The costimulatory blockade down-regulated the expression of 2 Th1 cytokines ( interferon-gamma [ IFN-gamma ] and interleukin-2 [ IL-2 ] ) and 2 Th2 cytokines ( IL-4 and IL-10 ), reduced the numbers of graft infiltrating CD4+ and CD8+ lymphocytes, and inhibited the expression of both perforin/GrB and FasL in allografts
Cohen et al., Am J Respir Cell Mol Biol 2009 : In contrast to Thy1 activation, TNF-alpha and IFN-gamma do not induce FasL myofibroblast up-regulation
Chakour et al., J Leukoc Biol 2009 : These results show that FasL synergizes with IFN-gamma to activate macrophages and that the tight regulation by IFN-gamma and/or IL-4 of the nonapoptotic signaling events triggered by the Fas-FasL pathway affects significantly the activation of macrophages to a microbicidal state and may thus contribute to the pathogenesis of L. major infection
Solarewicz-Madejek et al., Clin Exp Allergy 2009 (Asthma...) : IFN-gamma and TNF-alpha up-regulated TNFR1, TNFR2, Fas and membrane FasL on SMC
Galvão et al., Biol Reprod 2012 : In late CL cells, TNF and TNF+IFNG+FASL reduced VEGFR2 mRNA, but TNF+IFNG+FASL increased TSP1 and CD36 mRNA
Novelli et al., J Immunol 1997 : Apoptosis of both types of clones was mediated by autocrine or exogenous IFN-gamma through the up-regulation of Fas-L expression, since anti-IFN-gammaR alpha mAb inhibited its expression on Th1 and exogenous IFN-gamma increased its expression on Th2
Urayama et al., Biochem Biophys Res Commun 1997 : FasL expression was induced in CD4+ T cells cocultured with SEB pulsed EA.hy926 cells, especially when the EA.hy926 cells were IFN-gamma stimulated
Xu et al., Cancer Res 1998 (Leukemia, T-Cell) : IFN-gamma induces cell growth inhibition by Fas mediated apoptosis : requirement of STAT1 protein for up-regulation of Fas and FasL expression ... Here we report that IFN-gamma up-regulated the expression of Fas and Fas ligand (FasL) on HT29 cells, a human colon adenocarcinoma cell line, and subsequently induced apoptosis of these cells ... We further show that IFN-gamma up-regulated the expression of Fas and FasL in STAT1 transfected U3A cells but not in STAT1-deficient U3A cells
Shustov et al., J Immunol 1998 (Acute Disease...) : Differential expression of Fas and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-gamma production ... Thus, in this in vivo model of alloantigen immune responsiveness, Fas/FasL up-regulation is critically dependent on Ag-specific ( donor ) CD8+ T cell activation and IFN-gamma production