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IFNG — TLR9
Text-mined interactions from Literome
Pai et al., Infect Immun 2004
:
Microarray gene expression studies were then used to determine whether prolonged
TLR signaling by M. tuberculosis broadly
inhibits IFN-gamma regulation of macrophage gene expression
Kalis et al., J Immunol 2005
(Gram-Positive Bacterial Infections...) :
Because IFN-gamma is a key mediator of these effects, and enhanced IFN-gamma mRNA expression was absent in spleen and liver of P. acnes primed TLR9 ( -/- ) mice, we conclude that
TLR9 is
required for the induction of
IFN-gamma by P. acnes
Mueller et al., J Immunol 2006
:
The down-regulatory effect of Th2 cytokines on TLR expression and function in IECs also counteracted enhanced
TLR signaling
induced by stimulation with the hallmark Th1 cytokine
IFN-gamma
Eriksson et al., J Immunol 2006
:
However, purified uNK cells did not respond directly to TLR agonists, but
IFN-gamma was produced by uNK cells in
response to
TLR stimulation when cocultured with APCs
Velayudham et al., J Hepatol 2006
(Granuloma...) :
IFNgamma induction by P. acnes,
TLR2 and TLR9 ligands required MyD88
Ramakers et al., Cytokine 2006
:
In more detail, CPA potentiated TLR5 mediated IL-6 production,
TLR3 mediated
IFN-gamma production and TLR3 mediated Il-1beta production compared to TLR4 mediated stimulation
Yadav et al., J Leukoc Biol 2006
:
Functional analysis demonstrated that in vivo LPS conditioning endowed both the LPS-responsive and bystander cells with the ability to produce
IFN-gamma in
response to
TLR9 stimulation in vitro
Svensson et al., J Reprod Immunol 2007
(Herpes Genitalis) :
Lack of IFN-alpha/betaR signaling also blocked production of
IFN-gamma and TNF-alpha in
response to
TLR9 activation
Copin et al., J Immunol 2007
(Brucellosis) :
Using genetically deficient mice, we demonstrated that the induction of iNOS and
IFN-gamma producing cells due to Brucella infection
required TLR4 and
TLR9 stimulation coupled to Myd88 dependent signaling pathways
Girart et al., J Immunol 2007
(Melanoma) :
Engagement of TLR3,
TLR7 , and NKG2D
regulate IFN-gamma secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12
Barr et al., Eur J Immunol 2007
:
In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the
role of
Toll-like receptors ( TLR ) in the control of secretion of IL-6, IL-10, IL-12 and
IFN-gamma by B cells ... Thus, in
response to combined
TLR stimulation, or via phorbol esters,
IFN-gamma was secreted
Liese et al., Eur J Immunol 2007
(Leishmaniasis, Cutaneous) :
Here, we show that
TLR9 was
required for the induction of IL-12 in bone marrow derived DC by intact L. major parasites or L. major DNA and for the early
IFN-gamma expression and cytotoxicity of NK cells following infection with L. major in vivo
Allam et al., J Allergy Clin Immunol 2008
:
Moreover,
TLR4-ligation on oLCs
induced IL-10, TGF-beta1, Forkhead box protein 3,
IFN-gamma , and IL-2 production in T cells
O'Mahony et al., International journal of medical sciences 2008
:
Of the cytokines examined,
IFN-gamma and GM-CSF
caused the greatest effects on
TLR expression
Prescott et al., J Allergy Clin Immunol 2008
(Hypersensitivity...) :
Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and
IFN-gamma responses to TLR2,
TLR3 , and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Taylor et al., Blood 2008
(Graft vs Host Disease) :
We show that CpG ODNs markedly accelerated graft-versus-host disease ( GVHD ) lethality by
Toll-like receptor 9 (TLR9) ligation of host antigen presenting cells (APCs),
dependent upon host
IFNgamma but independent of host IL-12, IL-6, or natural killer ( NK ) cells
Archer et al., Cell Microbiol 2009
:
Thus, MyD88 dependent innate immune responses induced by L. pneumophila involve both
TLR dependent responses and IL-18R dependent production of
IFN-gamma by natural killer cells, and these MyD88 dependent pathways can function independently to provide host protection against an intracellular pathogen
Yarovinsky et al., J Immunol 2008
(Acute Disease...) :
We further show that this immunopathology is the result of
non-TLR dependent activation of
IFN-gamma secretion by NK cells in response to the infection
Lotter et al., PLoS Pathog 2009
(Disease Models, Animal...) :
IFN-gamma production by NKT cells
requires the presence of CD1d and simultaneously
TLR receptor signalling through MyD88 and secretion of IL-12
Bayas et al., Clin Exp Immunol 2009
(Bacterial Infections...) :
In an allogenic two-step co-culture assay we found an impaired
effect of
TLR-9 stimulation on
IFN-gamma expression of autologous naive T cells in MS patients ( n = 4 )
Devilder et al., J Immunol 2009
:
Moreover
TLR induced Vgamma9Vdelta2
IFN-gamma noncytolytic response led to efficient DC polarization into IL-12p70 producing cells
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon
(IFN)-gamma , interleukin-4, or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
van Hoffen et al., Int Arch Allergy Immunol 2010
:
Apically added LGG,
TLR2 and NOD2 ligands, but not Bb,
enhanced IFN-gamma , IL-12 and/or TNF-alpha secretion
Fang et al., FEMS Immunol Med Microbiol 2010
(West Nile Fever) :
Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or
toll-like receptor ( TLR ) agonist treatment of gammadelta T cells
induced the production of
IFN-gamma , tumor necrosis factor-alpha and IL-6, which are known to promote DC maturation
Bhan et al., PloS one 2010
(Pneumonia, Bacterial) :
Early lung expression of TNF-alpha, IL-12, and chemokines was TLR4 dependent, while
IFN-gamma production and the later expression of TNF-alpha and IL-12 was
dependent on
TLR9
Brisbin et al., Benef Microbes 2012
:
The results demonstrated that chicken CD4+ and CD8+ T-cells express
TLR21 and that the various isolates of lactobacilli differentially
induces the expression of interleukin 10,
interferon-gamma and transforming growth factor beta
Cheng et al., BMC gastroenterology 2013
(Celiac Disease) :
In CD subjects, the increased expression of IL-10 and
IFN-g may have partly
resulted from the increased
TLR9 expression and signaling