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CASP9 — IGF1
Text-mined interactions from Literome
Leverrier et al., Cell Death Differ 1999
:
Moreover, PI3-kinase activity is also necessary for inhibition of apoptosis and
caspase regulation by
IGF-1 but not IL-3
Takadera et al., J Neurochem 1999
:
Insulin-like growth factor I completely
attenuated MK-801 induced apoptotic cell death and
caspase-3 activation
Russell et al., Neurobiol Dis 1999
(Diabetes Mellitus, Experimental...) :
In contrast, addition of
IGF-I , even at physiological concentrations,
prevents activation of
caspase-3 and neuronal apoptosis in vitro
Matsuzaki et al., J Neurochem 1999
:
Incubation of neurons with a P13-kinase inhibitor, wortmannin or LY294002, blocked the
effects of
IGF-1 on NO-induced neurotoxicity and
caspase-3-like activation
Cheng et al., J Neurochem 2001
:
Insulin-like growth factor-I , via phosphatidylinositol-3 kinase,
inhibits caspase activation and rescues Schwann cells from serum withdrawal induced apoptosis
Kondo et al., Cell Death Differ 2002
:
Moreover,
IGF-1 inhibited C2-ceramide induced decrease of mitochondrial membrane potential, and increase of cytochrome c release, caspase-3 cleavage and
caspase-3 activity as judged by PhiPhiLux cleaving method ... Moreover,
IGF-1 inhibited C2-ceramide induced decrease of mitochondrial membrane potential, and increase of cytochrome c release, caspase-3 cleavage and
caspase-3 activity as judged by PhiPhiLux cleaving method
Linseman et al., J Neurosci 2002
:
IGF-I blocked activation of the executioner
caspase-3 and the intrinsic initiator caspase-9 in primary cerebellar granule neurons deprived of serum and depolarizing potassium
Burgess et al., J Neuroimmunol 2003
:
These data establish that
IGF-I inhibits activation of
caspase-3 and promotes promyeloid cell survival through a PI 3-kinase dependent pathway, whereas IL-3 does not
Lo et al., J Orthop Res 2004
:
Collagenase was added to the cells in the
presence and absence of
caspase inhibitors and insulin like growth factor
(IGF)-1
Ness et al., Glia 2004
:
IGF-I prevented glutamate induced loss of mitochondrial membrane potential, cytochrome c release, and
caspase-9 activation ... Moreover,
IGF-I prevented
caspase-3 activation in pro-OLs as long as 8 h after exposure of the cells to glutamate, suggesting that delayed activation of IGF-I mediated survival pathways can block glutamate mediated apoptosis in pro-OLs ... Moreover,
IGF-I prevented
caspase-3 activation in pro-OLs as long as 8 h after exposure of the cells to glutamate, suggesting that delayed activation of IGF-I mediated survival pathways can block glutamate mediated apoptosis in pro-OLs
Leinninger et al., Cell Death Differ 2004
(Neuroblastoma) :
IGF-I prevents
caspase activation and mitochondrial events leading to apoptosis ... These results suggest that elevated glucose produces early initiator
caspase activation, followed by Delta Psi ( M ) changes, in neuroblastoma cells ; in turn,
IGF-I prevents apoptosis by preventing downstream caspase activation, maintaining Delta Psi ( M ) and regulating Bcl proteins ... These results suggest that elevated glucose produces early initiator
caspase activation, followed by Delta Psi ( M ) changes, in neuroblastoma cells ; in turn,
IGF-I prevents apoptosis by preventing downstream caspase activation, maintaining Delta Psi ( M ) and regulating Bcl proteins
Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2005
:
Endogenous
IGF-I inhibited beta-catenin phosphorylation,
caspase 3 activation, and apoptosis induced by serum deprivation
Zhou et al., Zhong Xi Yi Jie He Xue Bao 2005
:
Immunohistochemical and integral optical density analytic methods were used to observe the
effects of Yiqi Huayu Recipe-, Yiqi Recipe-, Huayu Recipe medicated sera and
insulin-like growth factor 1 (IGF-1) on the expressions of bcl-2, Bax and
caspase-8 of apoptotic anulus fibrosus cells in rats induced by anti-Fas antibody
Kwon et al., Life Sci 2006
(Stomach Neoplasms) :
Thus, porphyran appears to negatively regulate
IGF-IR phosphorylation by causing a decrease in the expression levels in AGS gastric cancer cells, and then
inducing caspase-3 activation
Schlueter et al., Cell Death Differ 2007
:
At the cellular level,
IGF1R inhibition
increased caspase 3 activity and induced neuronal apoptosis
Meyer et al., J Cell Biochem 2007
(Neuroblastoma) :
NDGA inhibits growth of neuroblastoma cells and induces apoptosis at higher doses, causing
IGF-I-resistant activation of
caspase-3 and a large increase in the fraction of sub-G0 cells
Himpe et al., J Endocrinol 2008
:
IGF1 did not
affect Fas expression or activation by anti-Fas of
caspase-8 , but inhibited the depolarization of the mitochondrial membrane
Yang et al., BMC cancer 2009
(Colorectal Neoplasms) :
Using three colorectal cancer cell lines and one muscle cell line, associations between IGF-I and activities of caspase 3/7, 8 and 9 have been examined ; the
role of insulin-like growth factor I receptor (
IGF-IR ) in the
caspase activation has been investigated ... The results show that exogenous IGF-I significantly increases activity of caspases 3/7, 8 and 9 in all cell lines used ; blocking IGF-I receptor reduce
IGF-I induced
caspase activation ... Further studies demonstrate that
IGF-I induced
caspase activation does not result in cell death
Shushanov et al., Bull Exp Biol Med 2010
:
Insulin-like growth factor-1 and insulin
inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons ... Insulin and
insulin-like growth factor-1 and their combination
inhibit caspase-3/7 activation in these cells, induced by removal of the serum from culture medium and/or by IL-1ß treatment
Lai et al., Hum Gene Ther 2012
(Fibrosis...) :
Activation of
IGF-I expression
reduced cardiac fibrosis ( p=0.048 ), apoptosis ( p < 0.0001 ), and
caspase-3/7 activity ( p=0.04 )
Wang et al., Endocrinology 1998
:
To investigate IGF-I actions on apoptosis of H9C2 cardiac muscle cells, we have defined the
effects of
IGF-I on Bcl-2, Bax,
caspase 3, DNA fragmentation, and cell survival ...
IGF-I partially
inhibited Bax induction,
caspase 3 activation, DNA fragmentation, and enhanced cell survival
Russell et al., J Neurobiol 1998
:
We further studied the role of
IGF-I signaling and
caspase inhibition after NGF withdrawal ... Both
IGF-I and Boc-aspartyl ( OMe ) -fluoromethylketone ( BAF ), a
caspase inhibitor , equally reduced apoptosis after NGF withdrawal
Suzuki et al., FEBS Lett 1998
:
It was also found that R-Ras and
IGF-1 cooperatively induced Bcl-xL expression and
inhibited caspase-3 activation