UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to XRCC5

POLM — XRCC5

Pathways - manually collected, often from reviews:

NCI Pathway Database DNA-PK pathway in nonhomologous end joining: APLF (APLF) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/APLF complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-APLF) (modification, collaborate)
Iles et al., Mol Cell Biol 2007, Kanno et al., EMBO J 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: APLF (APLF) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Iles et al., Mol Cell Biol 2007, Kanno et al., EMBO J 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/APLF complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-APLF) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Iles et al., Mol Cell Biol 2007, Kanno et al., EMBO J 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: PNKP (PNKP) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/PNKP complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-PNKP) (modification, collaborate)
Koch et al., EMBO J 2004, Williams et al., Biochem Cell Biol 2005
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: PNKP (PNKP) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Koch et al., EMBO J 2004, Williams et al., Biochem Cell Biol 2005
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/PNKP complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-PNKP) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Koch et al., EMBO J 2004, Williams et al., Biochem Cell Biol 2005
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: XRCC4 (dimer)/Ligase IV complex (XRCC4-LIG4) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Nick McElhinny et al., Mol Cell Biol 2000, Chen et al., J Biol Chem 2000, Mahajan et al., Mol Cell Biol 2002, Nick McElhinny et al., Mol Cell Biol 2003, Modesti et al., J Mol Biol 2003, Drouet et al., J Biol Chem 2005, Ma et al., Mol Cell 2004, Costantini et al., DNA repair 2007, Gu et al., EMBO J 2007, Li et al., Cell 1995, Grawunder et al., Nature 1997, Leber et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: XRCC4 (dimer)/Ligase IV complex (XRCC4-LIG4) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM) (modification, collaborate)
Nick McElhinny et al., Mol Cell Biol 2000, Chen et al., J Biol Chem 2000, Mahajan et al., Mol Cell Biol 2002, Nick McElhinny et al., Mol Cell Biol 2003, Modesti et al., J Mol Biol 2003, Drouet et al., J Biol Chem 2005, Ma et al., Mol Cell 2004, Costantini et al., DNA repair 2007, Gu et al., EMBO J 2007, Li et al., Cell 1995, Grawunder et al., Nature 1997, Leber et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM) (modification, collaborate)
Nick McElhinny et al., Mol Cell Biol 2000, Chen et al., J Biol Chem 2000, Mahajan et al., Mol Cell Biol 2002, Nick McElhinny et al., Mol Cell Biol 2003, Modesti et al., J Mol Biol 2003, Drouet et al., J Biol Chem 2005, Ma et al., Mol Cell 2004, Costantini et al., DNA repair 2007, Gu et al., EMBO J 2007, Li et al., Cell 1995, Grawunder et al., Nature 1997, Leber et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Pol Mu (POLM) → Ku/Artemis/DNA-PKcs (dimer) complex (XRCC6-XRCC5-DCLRE1C-PRKDC) (modification, collaborate)
Mahajan et al., Mol Cell Biol 2002, Nick McElhinny et al., Mol Cell Biol 2003, Ma et al., Mol Cell 2004, Nick McElhinny et al., Mol Cell 2005, Davis et al., Nucleic Acids Res 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Pol Mu (POLM) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM) (modification, collaborate)
Mahajan et al., Mol Cell Biol 2002, Nick McElhinny et al., Mol Cell Biol 2003, Ma et al., Mol Cell 2004, Nick McElhinny et al., Mol Cell 2005, Davis et al., Nucleic Acids Res 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer) complex (XRCC6-XRCC5-DCLRE1C-PRKDC) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM) (modification, collaborate)
Mahajan et al., Mol Cell Biol 2002, Nick McElhinny et al., Mol Cell Biol 2003, Ma et al., Mol Cell 2004, Nick McElhinny et al., Mol Cell 2005, Davis et al., Nucleic Acids Res 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Aprataxin (APTX) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/Aprataxin complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-APTX) (modification, collaborate)
Clements et al., DNA repair 2004, Ahel et al., Nature 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Aprataxin (APTX) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Clements et al., DNA repair 2004, Ahel et al., Nature 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/Aprataxin complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-APTX) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Clements et al., DNA repair 2004, Ahel et al., Nature 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: 0005956 () → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, activates)
Clements et al., DNA repair 2004, Koch et al., EMBO J 2004, Iles et al., Mol Cell Biol 2007, Kanno et al., EMBO J 2007
Evidence: mutant phenotype, assay
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/XLF (dimer) complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-NHEJ1) → XLF (dimer) complex (NHEJ1) (modification, collaborate)
Ahnesorg et al., Cell 2006, Callebaut et al., J Biol Chem 2006, Tsai et al., Proc Natl Acad Sci U S A 2007, Gu et al., Nucleic Acids Res 2007, Li et al., EMBO J 2008, Andres et al., Mol Cell 2007
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/XLF (dimer) complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-NHEJ1) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Ahnesorg et al., Cell 2006, Callebaut et al., J Biol Chem 2006, Tsai et al., Proc Natl Acad Sci U S A 2007, Gu et al., Nucleic Acids Res 2007, Li et al., EMBO J 2008, Andres et al., Mol Cell 2007
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: XLF (dimer) complex (NHEJ1) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Ahnesorg et al., Cell 2006, Callebaut et al., J Biol Chem 2006, Tsai et al., Proc Natl Acad Sci U S A 2007, Gu et al., Nucleic Acids Res 2007, Li et al., EMBO J 2008, Andres et al., Mol Cell 2007
Evidence: mutant phenotype, assay, physical interaction