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NFKB1 — VEGFA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Marumo et al., Diabetes 1999
:
Using electrophoretic gel mobility shift assay, we observed that
VEGF stimulated binding activity of
NF-kappaB ...
VEGF induced
NF-kappaB activation was inhibited by TLCK and NAC, but not by PD 98059
Mechtcheriakova et al., Blood 1999
(Inflammation) :
In contrast,
NFkappaB , the major transcription factor involved in tissue factor upregulation by inflammatory stimuli, is not
activated by
VEGF
Ohm et al., J Immunol 1999
:
VEGF inhibited FL-inducible activation of transcription factor
NF-kappaB
Kim et al., J Biol Chem 2001
:
Gel shift analysis revealed that
VEGF stimulated
NF-kappaB activity
Bancroft et al., Clin Cancer Res 2001
(Carcinoma, Squamous Cell...) :
Expression of IL-8 and
VEGF in the cell lines was associated with coactivation of both NF-kappaB and AP-1, and U0126
inhibited both
NF-kappaB and AP-1 reporter activity in UM-SCC-9 and UM-SCC-11B cells
Dikov et al., Cancer Res 2001
:
VEGF effectively
blocked TNF-alpha induced
NF-kappaB activation in HPCs from RelB-/- mice, however, similar to the effect observed in HPCs obtained from RelB+/- and RelB+/+ mice
Wang et al., Biochem Biophys Res Commun 2001
(Arteriosclerosis) :
VEGF increased intracellular reactive oxygen species ( ROS ),
NF-kappaB activation and IL-6 expression ... Blockade of the generation of intracellular ROS by antioxidants inhibited
VEGF induced
NF-kappaB activation, IL-6 expression, and cell migration indicating that generation of ROS was required for NF-kappaB activation and the chemotactic activity of VEGF
Kim et al., FASEB J 2002
:
Using human umbilical vein endothelial cells, we found that inhibitors of guanine-cytosine-rich DNA binding protein and
nuclear factor (NF)-kB suppressed
VEGF- and TNF-a induced expression and activity of TF
Loewe et al., J Immunol 2002
:
We show that DMF inhibits TNF induced tissue factor mRNA and protein expression as well as TNF induced DNA binding of
NF-kappa B proteins, but not
VEGF induced tissue factor protein, mRNA expression, or VEGF induced early gene response-1 transcription factor/DNA binding
Bancroft et al., Int J Cancer 2002
(Carcinoma, Squamous Cell...) :
Recombinant EGF induced EGFR phosphorylation,
activation of
NF-kappaB and AP-1 reporter genes and IL-8 and
VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC
Shibata et al., Breast Cancer Res Treat 2002
(Breast Neoplasms...) :
On the other hand, constitutive expression of a transcription factor, NF-kappaB was correlated with progression and metastasis in a number of human breast cancers, suggesting a possible
regulation of
VEGF expression by
NF-kappaB
Ding et al., Mol Cell Biochem 2002
(Cell Transformation, Neoplastic) :
This article summarizes recent studies from our laboratory on ( a ) the reduction of Cr ( VI ) by ascorbate, diol- and thiol containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals ; ( b ) free radical production in both non-cellular and cellular systems ; and ( c) Cr(VI ) -induced DNA damage,
activation of nuclear transcription factor KB (
NF-kappaB ), activator protein-1, p53, hypoxia-inducible factor-1,
vascular endothelial growth factor , tyrosine phosphorylation, apoptosis, cell growth arrest, and gene expression profile
Raychaudhuri et al., Clin Immunol 2002
(Hypertension, Pulmonary) :
However, mRNA expression was decreased compared to controls for
NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor, interleukin-6, macrophage inflammatory protein-1alpha ( MIP-1alpha ), and
vascular endothelial growth factor
Yoshizaki et al., Histol Histopathol 2002
(Carcinoma...) :
LMP-1 also
induces vascular endothelial growth factor through cyclooxygenase-2 activation and interleukin-8 through
NF-kappaB activation
Masuda et al., J Exp Ther Oncol 2002
(Breast Neoplasms...) :
An analysis of alternative pathways indicated that EGCG strongly inhibited the constitutive activation of NF-kappa B in both cell lines, and an
NF-kappa B inhibitor strongly
inhibited VEGF production ... These results suggest that EGCG
inhibits VEGF production by inhibiting both the constitutive activation of Stat3 and
NF-kappa B , but not extracellular-signal regulated kinase ( ERK ) or Akt, in these cells
Fujioka et al., Clin Cancer Res 2003
(Neoplasm Metastasis...) :
Inhibiting
NFkappaB activation by expressing IkappaBalphaM and using pharmacologic NFkappaB inhibitor PS-341 also significantly
reduced cytokine induced
vascular endothelial growth factor and interleukin-8 expression in AsPc-1 pancreatic cancer cells
Kiriakidis et al., J Cell Sci 2003
(Inflammation...) :
VEGF expression in human macrophages is
NF-kappaB dependent : studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2 ... Because LPS and CD40L activate nuclear factor-kappaB (NF-kappaB) in monocytes, we investigated in this study whether
VEGF production in macrophages, when stimulated with either LPS or CD40L, is
NF-kappaB dependent ... These results show for the first time that
VEGF production in human macrophages is
NF-kappaB dependent
Nagineni et al., J Cell Physiol 2003
(MAP Kinase Signaling System...) :
VEGF mRNA levels and protein secretion induced by TGF-beta were significantly
inhibited by SB203580 and U0126, inhibitors of MAP kinases, but not by staurosporine and PDTC, protein kinase C and
NF-kappaB pathway inhibitors, respectively
Distler et al., Mol Pharmacol 2004
(Scleroderma, Systemic) :
The study provides evidence for a
role of
NF-kappaB in the transcriptional regulation of the
VEGF gene
Mamputu et al., Diabetes Obes Metab 2004
(MAP Kinase Signaling System) :
Our results demonstrate the
involvement of PKC, MAPK and
NF-kappaB in AGE induced BREC proliferation and
VEGF expression
Zhang et al., J Huazhong Univ Sci Technolog Med Sci 2004
:
In order to investigate the
effect of
nuclear factor-kappa B (NF-kappaB) on
vascular endothelial growth factor ( VEGF ) mRNA expression of human pulmonary artery smooth muscle cells ( HPASMCs ) in hypoxia, the cultured HPASMCs in vitro were stimulated with pyrrolidine dithiocarbamate ( PDTC ), an inhibitor of NF-kappaB ... It is suggested that the activation of
NF-kappaB is
involved in the
VEGF mRNA expression of HPASMCs under hypoxia
Shukla et al., Neoplasia (New York, N.Y.) 2004
(Adenocarcinoma...) :
The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of Bcl2, cyclin D1, MMP-9, and
VEGF
Abid et al., J Biol Chem 2004
:
VEGF resulted in protein kinase C-dependent phosphorylation of IkappaB and subsequent translocation of p65
NF-kappaB into the nucleus
Fujioka et al., Mol Cell Biol 2004
:
Thus, our study revealed a distinct and essential
role of
NF-kappaB in participating in the regulation of elk-1, c-fos, and
VEGF expression
Wu et al., World J Gastroenterol 2005
(Helicobacter Infections...) :
These effects appear to be mediated through a NF-kappaB and COX-2 mediated pathway, as COX-2 or
NF-kappaB inhibitor significantly
attenuate the invasiveness of gastric cancer cells and the expressions of MMP-9 and
VEGF protein
Maeng et al., Cell Signal 2006
:
Consistently, inhibition of ERK significantly increased IkappaB kinase (IKK) activity, IkappaBalpha phosphorylation, and nuclear translocation of
NF-kappaB induced by
VEGF , whereas overexpression of ERK resulted in the loss of these responses to VEGF
Grosjean et al., Biochem Biophys Res Commun 2006
(Neovascularization, Pathologic) :
This study aimed to address the hypothesis that
VEGF mediated survival effects on endothelium involve
NFkappaB
Tong et al., Respir Res 2006
:
Deletion of NF-kappaB binding sites within VEGF promoter abolished HIMF induced VEGF expression in MLE-12 cells, suggesting that activation of
NF-kappaB is
essential for
VEGF upregulation induced by HIMF
Ko et al., FEBS Lett 2006
:
Platelet activating factor induced
NF-kappaB activation
enhances VEGF expression through a decrease in p53 activity ... We investigated the role of p53 in
nuclear factor (NF)-kappaB dependent , platelet activating factor (PAF) induced
vascular endothelial growth factor ( VEGF ) expression
Yamagishi et al., J Biol Chem 2006
(Diabetic Retinopathy) :
This led to blockade of the AGE elicited Ras activation and
NF-kappaB dependent
VEGF gene induction in endothelial cells
Abid et al., J Biol Chem 2006
:
VEGF induction of the forkhead dependent genes was
down-regulated by the
NF-kappaB inhibitor, constitutively active Ad-IkappaB, and in some cases by the nuclear factor of activated T-cells ( NF-AT ) inhibitor, cyclosporin
Zheng et al., Zhonghua Yi Xue Za Zhi 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
STI571 could promote the activation/maturation of DC derived from BMMNCs of patients with CML in vitro, which might be partially responsible for the fact that the inhibitory
effect of
VEGF on DC
NF-kappaB activation was relieved through STI571 inhibiting the overproduction of VEGF in CML
Ramanathan et al., Mol Biol Cell 2007
:
Deletion of putative NF-kappaB binding sites from the VEGF promoter did not affect LPS/NECA induced VEGF promoter activity, suggesting that
NF-kappaB is not directly
involved in
VEGF transcription
Hsu et al., Food Chem Toxicol 2007
(Carcinoma, Hepatocellular...) :
Furthermore, EAC also inhibited the TNF-alpha activated
NF-kappaB dependent reporter gene expression of MMP-9 and
VEGF , and the invasion of cancer cells
Ma et al., Invest Ophthalmol Vis Sci 2007
:
RAGE mediated upregulation of
VEGF secretion by ARPE-19 cells was largely
dependent on
NF-kappaB , as indicated by studies with parthenolide ...
NF-kappaB plays a central role in RAGE dependent RPE secretion of
VEGF
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and
vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Sandur et al., Carcinogenesis 2007
:
The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2, cyclin D1 and
vascular endothelial growth factor , all
regulated by
NF-kappaB
Amin et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
IL-18 induced RA ST fibroblast production of
VEGF was
mediated mainly by JNK-2, PKCalpha, and
NFkappaB
Meng et al., Am J Physiol Cell Physiol 2007
(Liver Neoplasms, Experimental...) :
Moreover, Akt was involved in
NF-kappaB dependent
VEGF expression and angiogenesis
Crisostomo et al., Am J Physiol Cell Physiol 2008
:
VEGF , FGF2, and HGF expression was significantly
reduced by
NF kappa B inhibition ( 50 % decrease ) but not ERK or JNK inhibition ... Moreover, ERK, JNK, and
NF kappa B inhibitor alone did not
activate MSC
VEGF expression over controls
Hu et al., Cell Signal 2008
(Burkitt Lymphoma...) :
The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or
NFkappaB activation inhibited LPA
induced VEGF expression
Ohba et al., J Orthop Res 2009
(Intervertebral Disc Displacement) :
NF-kappaB pathway inhibitors also strongly
suppressed VEGF induction
Moreira et al., Invest Ophthalmol Vis Sci 2009
(Choroidal Neovascularization) :
Inhibition of
NF-kappaB with BAY 11-7082
reduced IL-8 but not
VEGF induction
Park et al., Vascul Pharmacol 2009
:
In HT1080 cancer cells, FPP-3 significantly suppressed release of
VEGF as well as
activation of
NF-kappaB , a transcriptional factor required for VEGF expression
Wu et al., Cancer Lett 2009
(Carcinoma, Hepatocellular...) :
Inhibition of
NF-kappaB activity significantly reduced proliferation and invasion of Hep3B cells as well as
down-regulated the expression of invasion related molecules including matrix metalloproteinase (MMP)-2, MMP-9, membrane type-1 MMP (MT1-MMP), urokinase plasminogen activator (uPA) and
vascular endothelial growth factor ( VEGF )
Zhang et al., Cell Prolif 2009
(Carcinoma, Adenoid Cystic...) :
NF-kappaB promotes iNOS and
VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro ... Conclusions : Our results suggest that
NF-kappaB promotes iNOS and
VEGF expression in salivary gland ACC cells and enhances endothelial cell motility in vitro
Szczepanski et al., Cancer Res 2009
(Carcinoma, Squamous Cell...) :
LPS binding to TLR4 on tumor cells enhanced proliferation, activated phosphatidylinositol 3-kinase/Akt pathway, up-regulated IRAK-4 expression,
induced nuclear
NF-kappaB translocation, and increased production ( P < 0.05 ) of interleukin (IL)-6, IL-8,
vascular endothelial growth factor , and granulocyte macrophage colony stimulating factor
Quiles-Perez et al., Hepatology 2010
(Carcinoma, Hepatocellular...) :
Furthermore, the results obtained in mice treated with DEN to induce hepatocarcinogenesis showed, after treatment with a PARP inhibitor ( DPQ ), a significant reduction both in preneoplastic foci and in the expression of preneoplastic markers and proinflammatory genes ( Gstm3,
Vegf , Spp1 [ Opn ], IL6, IL1b, and Tnf ), bromodeoxyuridine incorporation, and
NF-kappaB activation in the initial steps of carcinogenesis ( P < 0.05 )
Liu et al., Cancer Invest 2010
(Neovascularization, Pathologic) :
The role of
NF-kappaB in Hepatitis b virus X protein
mediated upregulation of
VEGF and MMPs ... This study investigated the
role of
NF-kappa B in HBx mediated upregulation of
vascular endothelial growth factor ( VEGF ) and matrix metalloproteinases ( MMPs )
Xie et al., Oncol Rep 2010
(Glioblastoma...) :
Constitutive
NF-kappaB activity
regulates the expression of
VEGF and IL-8 and tumor angiogenesis of human glioblastoma
Kaus et al., Stem Cells Dev 2010
:
Neural stem cells adopt tumorigenic properties by constitutively activated
NF-kappaB and subsequent
VEGF up-regulation
Trebec-Reynolds et al., J Cell Biochem 2010
:
VEGF-A expression in osteoclasts is
regulated by
NF-kappaB induction of HIF-1alpha
Gonzalez-Perez et al., Cell Signal 2010
(Mammary Neoplasms, Experimental) :
Deletion analysis of VEGF promoter and RNA knockdown shows that HIF-1alpha and
NFkappaB are
essentials for leptin regulation of
VEGF
Leychenko et al., PloS one 2011
(Cardiomegaly) :
Stretch induced hypertrophy activates
NFkB mediated
VEGF secretion in adult cardiomyocytes ... Cyclic mechanical stretch mediated
VEGF secretion was
blocked by an
NFkB peptide inhibitor and expression of a dominant negative mutant IkBa, but not by inhibitors of the MAPK/ERK1/2 or PI3K pathways
He et al., Bing Du Xue Bao 2012
(Dengue...) :
In addition,
VEGF induction by DENV2 was significantly
impaired by knockdown of TLR3 and interferon-beta promoter stimulator 1 ( IPS-1 ), or by inhibition of ERK, JNK or
NF-kappaB
Klettner et al., Molecular vision 2013
(MAP Kinase Signaling System) :
Inhibition of the transcription factor
NFkB diminished
VEGF secretion after 6 h ( earliest measured time point ) and remained diminished at all measured time points ( 24 h, 48 h )
Oyama et al., J Immunol 1998
:
VEGF significantly
inhibited nuclear factor-kappa B (NF-kappa B)-dependent activation of reporter gene transcription during the first 24 h in culture