Gene interactions and pathways from curated databases and text-mining

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NFKB1 — VEGFA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Marumo et al., Diabetes 1999 : Using electrophoretic gel mobility shift assay, we observed that VEGF stimulated binding activity of NF-kappaB ... VEGF induced NF-kappaB activation was inhibited by TLCK and NAC, but not by PD 98059
Mechtcheriakova et al., Blood 1999 (Inflammation) : In contrast, NFkappaB , the major transcription factor involved in tissue factor upregulation by inflammatory stimuli, is not activated by VEGF
Ohm et al., J Immunol 1999 : VEGF inhibited FL-inducible activation of transcription factor NF-kappaB
Kim et al., J Biol Chem 2001 : Gel shift analysis revealed that VEGF stimulated NF-kappaB activity
Bancroft et al., Clin Cancer Res 2001 (Carcinoma, Squamous Cell...) : Expression of IL-8 and VEGF in the cell lines was associated with coactivation of both NF-kappaB and AP-1, and U0126 inhibited both NF-kappaB and AP-1 reporter activity in UM-SCC-9 and UM-SCC-11B cells
Dikov et al., Cancer Res 2001 : VEGF effectively blocked TNF-alpha induced NF-kappaB activation in HPCs from RelB-/- mice, however, similar to the effect observed in HPCs obtained from RelB+/- and RelB+/+ mice
Wang et al., Biochem Biophys Res Commun 2001 (Arteriosclerosis) : VEGF increased intracellular reactive oxygen species ( ROS ), NF-kappaB activation and IL-6 expression ... Blockade of the generation of intracellular ROS by antioxidants inhibited VEGF induced NF-kappaB activation, IL-6 expression, and cell migration indicating that generation of ROS was required for NF-kappaB activation and the chemotactic activity of VEGF
Kim et al., FASEB J 2002 : Using human umbilical vein endothelial cells, we found that inhibitors of guanine-cytosine-rich DNA binding protein and nuclear factor (NF)-kB suppressed VEGF- and TNF-a induced expression and activity of TF
Loewe et al., J Immunol 2002 : We show that DMF inhibits TNF induced tissue factor mRNA and protein expression as well as TNF induced DNA binding of NF-kappa B proteins, but not VEGF induced tissue factor protein, mRNA expression, or VEGF induced early gene response-1 transcription factor/DNA binding
Bancroft et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : Recombinant EGF induced EGFR phosphorylation, activation of NF-kappaB and AP-1 reporter genes and IL-8 and VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC
Shibata et al., Breast Cancer Res Treat 2002 (Breast Neoplasms...) : On the other hand, constitutive expression of a transcription factor, NF-kappaB was correlated with progression and metastasis in a number of human breast cancers, suggesting a possible regulation of VEGF expression by NF-kappaB
Ding et al., Mol Cell Biochem 2002 (Cell Transformation, Neoplastic) : This article summarizes recent studies from our laboratory on ( a ) the reduction of Cr ( VI ) by ascorbate, diol- and thiol containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals ; ( b ) free radical production in both non-cellular and cellular systems ; and ( c) Cr(VI ) -induced DNA damage, activation of nuclear transcription factor KB ( NF-kappaB ), activator protein-1, p53, hypoxia-inducible factor-1, vascular endothelial growth factor , tyrosine phosphorylation, apoptosis, cell growth arrest, and gene expression profile
Raychaudhuri et al., Clin Immunol 2002 (Hypertension, Pulmonary) : However, mRNA expression was decreased compared to controls for NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor, interleukin-6, macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 also induces vascular endothelial growth factor through cyclooxygenase-2 activation and interleukin-8 through NF-kappaB activation
Masuda et al., J Exp Ther Oncol 2002 (Breast Neoplasms...) : An analysis of alternative pathways indicated that EGCG strongly inhibited the constitutive activation of NF-kappa B in both cell lines, and an NF-kappa B inhibitor strongly inhibited VEGF production ... These results suggest that EGCG inhibits VEGF production by inhibiting both the constitutive activation of Stat3 and NF-kappa B , but not extracellular-signal regulated kinase ( ERK ) or Akt, in these cells
Fujioka et al., Clin Cancer Res 2003 (Neoplasm Metastasis...) : Inhibiting NFkappaB activation by expressing IkappaBalphaM and using pharmacologic NFkappaB inhibitor PS-341 also significantly reduced cytokine induced vascular endothelial growth factor and interleukin-8 expression in AsPc-1 pancreatic cancer cells
Kiriakidis et al., J Cell Sci 2003 (Inflammation...) : VEGF expression in human macrophages is NF-kappaB dependent : studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2 ... Because LPS and CD40L activate nuclear factor-kappaB (NF-kappaB) in monocytes, we investigated in this study whether VEGF production in macrophages, when stimulated with either LPS or CD40L, is NF-kappaB dependent ... These results show for the first time that VEGF production in human macrophages is NF-kappaB dependent
Nagineni et al., J Cell Physiol 2003 (MAP Kinase Signaling System...) : VEGF mRNA levels and protein secretion induced by TGF-beta were significantly inhibited by SB203580 and U0126, inhibitors of MAP kinases, but not by staurosporine and PDTC, protein kinase C and NF-kappaB pathway inhibitors, respectively
Distler et al., Mol Pharmacol 2004 (Scleroderma, Systemic) : The study provides evidence for a role of NF-kappaB in the transcriptional regulation of the VEGF gene
Mamputu et al., Diabetes Obes Metab 2004 (MAP Kinase Signaling System) : Our results demonstrate the involvement of PKC, MAPK and NF-kappaB in AGE induced BREC proliferation and VEGF expression
Zhang et al., J Huazhong Univ Sci Technolog Med Sci 2004 : In order to investigate the effect of nuclear factor-kappa B (NF-kappaB) on vascular endothelial growth factor ( VEGF ) mRNA expression of human pulmonary artery smooth muscle cells ( HPASMCs ) in hypoxia, the cultured HPASMCs in vitro were stimulated with pyrrolidine dithiocarbamate ( PDTC ), an inhibitor of NF-kappaB ... It is suggested that the activation of NF-kappaB is involved in the VEGF mRNA expression of HPASMCs under hypoxia
Shukla et al., Neoplasia (New York, N.Y.) 2004 (Adenocarcinoma...) : The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with NF-kappaB dependent expression of Bcl2, cyclin D1, MMP-9, and VEGF
Abid et al., J Biol Chem 2004 : VEGF resulted in protein kinase C-dependent phosphorylation of IkappaB and subsequent translocation of p65 NF-kappaB into the nucleus
Fujioka et al., Mol Cell Biol 2004 : Thus, our study revealed a distinct and essential role of NF-kappaB in participating in the regulation of elk-1, c-fos, and VEGF expression
Wu et al., World J Gastroenterol 2005 (Helicobacter Infections...) : These effects appear to be mediated through a NF-kappaB and COX-2 mediated pathway, as COX-2 or NF-kappaB inhibitor significantly attenuate the invasiveness of gastric cancer cells and the expressions of MMP-9 and VEGF protein
Maeng et al., Cell Signal 2006 : Consistently, inhibition of ERK significantly increased IkappaB kinase (IKK) activity, IkappaBalpha phosphorylation, and nuclear translocation of NF-kappaB induced by VEGF , whereas overexpression of ERK resulted in the loss of these responses to VEGF
Grosjean et al., Biochem Biophys Res Commun 2006 (Neovascularization, Pathologic) : This study aimed to address the hypothesis that VEGF mediated survival effects on endothelium involve NFkappaB
Tong et al., Respir Res 2006 : Deletion of NF-kappaB binding sites within VEGF promoter abolished HIMF induced VEGF expression in MLE-12 cells, suggesting that activation of NF-kappaB is essential for VEGF upregulation induced by HIMF
Ko et al., FEBS Lett 2006 : Platelet activating factor induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity ... We investigated the role of p53 in nuclear factor (NF)-kappaB dependent , platelet activating factor (PAF) induced vascular endothelial growth factor ( VEGF ) expression
Yamagishi et al., J Biol Chem 2006 (Diabetic Retinopathy) : This led to blockade of the AGE elicited Ras activation and NF-kappaB dependent VEGF gene induction in endothelial cells
Abid et al., J Biol Chem 2006 : VEGF induction of the forkhead dependent genes was down-regulated by the NF-kappaB inhibitor, constitutively active Ad-IkappaB, and in some cases by the nuclear factor of activated T-cells ( NF-AT ) inhibitor, cyclosporin
Zheng et al., Zhonghua Yi Xue Za Zhi 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : STI571 could promote the activation/maturation of DC derived from BMMNCs of patients with CML in vitro, which might be partially responsible for the fact that the inhibitory effect of VEGF on DC NF-kappaB activation was relieved through STI571 inhibiting the overproduction of VEGF in CML
Ramanathan et al., Mol Biol Cell 2007 : Deletion of putative NF-kappaB binding sites from the VEGF promoter did not affect LPS/NECA induced VEGF promoter activity, suggesting that NF-kappaB is not directly involved in VEGF transcription
Hsu et al., Food Chem Toxicol 2007 (Carcinoma, Hepatocellular...) : Furthermore, EAC also inhibited the TNF-alpha activated NF-kappaB dependent reporter gene expression of MMP-9 and VEGF , and the invasion of cancer cells
Ma et al., Invest Ophthalmol Vis Sci 2007 : RAGE mediated upregulation of VEGF secretion by ARPE-19 cells was largely dependent on NF-kappaB , as indicated by studies with parthenolide ... NF-kappaB plays a central role in RAGE dependent RPE secretion of VEGF
Kunnumakkara et al., Cancer Res 2007 (Neovascularization, Pathologic...) : In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ), NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Sandur et al., Carcinogenesis 2007 : The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2, cyclin D1 and vascular endothelial growth factor , all regulated by NF-kappaB
Amin et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid) : IL-18 induced RA ST fibroblast production of VEGF was mediated mainly by JNK-2, PKCalpha, and NFkappaB
Meng et al., Am J Physiol Cell Physiol 2007 (Liver Neoplasms, Experimental...) : Moreover, Akt was involved in NF-kappaB dependent VEGF expression and angiogenesis
Crisostomo et al., Am J Physiol Cell Physiol 2008 : VEGF , FGF2, and HGF expression was significantly reduced by NF kappa B inhibition ( 50 % decrease ) but not ERK or JNK inhibition ... Moreover, ERK, JNK, and NF kappa B inhibitor alone did not activate MSC VEGF expression over controls
Hu et al., Cell Signal 2008 (Burkitt Lymphoma...) : The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or NFkappaB activation inhibited LPA induced VEGF expression
Ohba et al., J Orthop Res 2009 (Intervertebral Disc Displacement) : NF-kappaB pathway inhibitors also strongly suppressed VEGF induction
Moreira et al., Invest Ophthalmol Vis Sci 2009 (Choroidal Neovascularization) : Inhibition of NF-kappaB with BAY 11-7082 reduced IL-8 but not VEGF induction
Park et al., Vascul Pharmacol 2009 : In HT1080 cancer cells, FPP-3 significantly suppressed release of VEGF as well as activation of NF-kappaB , a transcriptional factor required for VEGF expression
Wu et al., Cancer Lett 2009 (Carcinoma, Hepatocellular...) : Inhibition of NF-kappaB activity significantly reduced proliferation and invasion of Hep3B cells as well as down-regulated the expression of invasion related molecules including matrix metalloproteinase (MMP)-2, MMP-9, membrane type-1 MMP (MT1-MMP), urokinase plasminogen activator (uPA) and vascular endothelial growth factor ( VEGF )
Zhang et al., Cell Prolif 2009 (Carcinoma, Adenoid Cystic...) : NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro ... Conclusions : Our results suggest that NF-kappaB promotes iNOS and VEGF expression in salivary gland ACC cells and enhances endothelial cell motility in vitro
Szczepanski et al., Cancer Res 2009 (Carcinoma, Squamous Cell...) : LPS binding to TLR4 on tumor cells enhanced proliferation, activated phosphatidylinositol 3-kinase/Akt pathway, up-regulated IRAK-4 expression, induced nuclear NF-kappaB translocation, and increased production ( P < 0.05 ) of interleukin (IL)-6, IL-8, vascular endothelial growth factor , and granulocyte macrophage colony stimulating factor
Quiles-Perez et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : Furthermore, the results obtained in mice treated with DEN to induce hepatocarcinogenesis showed, after treatment with a PARP inhibitor ( DPQ ), a significant reduction both in preneoplastic foci and in the expression of preneoplastic markers and proinflammatory genes ( Gstm3, Vegf , Spp1 [ Opn ], IL6, IL1b, and Tnf ), bromodeoxyuridine incorporation, and NF-kappaB activation in the initial steps of carcinogenesis ( P < 0.05 )
Liu et al., Cancer Invest 2010 (Neovascularization, Pathologic) : The role of NF-kappaB in Hepatitis b virus X protein mediated upregulation of VEGF and MMPs ... This study investigated the role of NF-kappa B in HBx mediated upregulation of vascular endothelial growth factor ( VEGF ) and matrix metalloproteinases ( MMPs )
Xie et al., Oncol Rep 2010 (Glioblastoma...) : Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma
Kaus et al., Stem Cells Dev 2010 : Neural stem cells adopt tumorigenic properties by constitutively activated NF-kappaB and subsequent VEGF up-regulation
Trebec-Reynolds et al., J Cell Biochem 2010 : VEGF-A expression in osteoclasts is regulated by NF-kappaB induction of HIF-1alpha
Gonzalez-Perez et al., Cell Signal 2010 (Mammary Neoplasms, Experimental) : Deletion analysis of VEGF promoter and RNA knockdown shows that HIF-1alpha and NFkappaB are essentials for leptin regulation of VEGF
Leychenko et al., PloS one 2011 (Cardiomegaly) : Stretch induced hypertrophy activates NFkB mediated VEGF secretion in adult cardiomyocytes ... Cyclic mechanical stretch mediated VEGF secretion was blocked by an NFkB peptide inhibitor and expression of a dominant negative mutant IkBa, but not by inhibitors of the MAPK/ERK1/2 or PI3K pathways
He et al., Bing Du Xue Bao 2012 (Dengue...) : In addition, VEGF induction by DENV2 was significantly impaired by knockdown of TLR3 and interferon-beta promoter stimulator 1 ( IPS-1 ), or by inhibition of ERK, JNK or NF-kappaB
Klettner et al., Molecular vision 2013 (MAP Kinase Signaling System) : Inhibition of the transcription factor NFkB diminished VEGF secretion after 6 h ( earliest measured time point ) and remained diminished at all measured time points ( 24 h, 48 h )
Oyama et al., J Immunol 1998 : VEGF significantly inhibited nuclear factor-kappa B (NF-kappa B)-dependent activation of reporter gene transcription during the first 24 h in culture