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IL10 — IL18

Text-mined interactions from Literome

Qiu et al., Zhongguo Yao Li Xue Bao 1999 : Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages
Kohka et al., J Immunol 2000 : Histamine ( 10-7 to 10-4 M ) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine in the same concentration range did not induce the production of IL-12 at all
Kelly et al., Reproduction 2001 : Prostaglandins have major effects on cytokine production but the direct action of prostaglandin E on leucocytes is not a pro-inflammatory response but is to stimulate interleukin 10 and inhibit interleukin 12 synthesis
Yamaguchi et al., Dig Dis Sci 2000 : Interleukin-12 and -18 mRNA transcripts in an allogeneic mixed lymphocyte reaction were inhibited by interleukin-10 and transforming growth factor-beta
Ohe et al., Cancer Immunol Immunother 2001 (Fibrosarcoma...) : Furthermore, IL-12 and IL-18 induced by AILb-A inhibited specifically IL-10 and IL-4 production, respectively
Chakir et al., Cell Immunol 2001 : DX5+ splenocytes showed a rapid ( 6 h ) and sustained ( 6-72 h ) accumulation of IFN-gamma transcripts followed by a delayed ( 12-24 h ) up-regulation of IL-10 or IL-13 expression in response to IL-2 + IL-12 or IL-2 + IL-18 , respectively
Böcker et al., Eur Cytokine Netw 2001 : Secretion of IL-18 was independent of functional activity of IL-10 , IL-12 or IFN-gamma
Byrnes et al., Ann Neurol 2002 (Multiple Sclerosis, Chronic Progressive...) : Interleukin-10 , a dominant endogenous inhibitor of interleukin-12 , is largely protective in these experimental surrogates for multiple sclerosis
Puliti et al., Arthritis Rheum 2002 (Arthritis, Infectious...) : The beneficial effect of interleukin-12 on arthritis induced by group B streptococci is mediated by interferon-gamma and interleukin-10 production
Uchimura et al., Clin Exp Immunol 2002 (Graves Disease) : The effects of CD40- and interleukin ( IL-4 ) -activated CD23+ cells on the production of IL-10 by mononuclear cells in Graves ' disease : the role of CD8+ cells
Perez et al., Blood 2003 (Burkitt Lymphoma...) : FL plus IL-15-driven ACF/CD56 ( + ) cells progressively expressed a mature NK functional program lysing both NK- and lymphokine-activate killer ( LAK ) -sensitive tumor targets and producing high levels of interferon-gamma (IFN-gamma), granulocyte-macrophage colony stimulating factor, tumor necrosis factor alpha, and IL-10 upon stimulation with IL-12 and IL-18
Weinstock et al., J Immunol 2003 : Splenic T cells exposed to IL-12 or IL-18 in the presence of IL-10 expressed no NK-1R mRNA
Schröder et al., J Immunol 2003 : In an in vitro IL-12/IL-18 responsiveness model, we demonstrated that IL-10 , if permanently present, does not directly inhibit IL-12/IL-18 responsiveness in T/NK cells but indirectly interferes with IFN-gamma production in the presence of monocytes
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Chiang et al., Am J Respir Crit Care Med 2003 (Asthma...) : The data showed that ribavirin and ODN 1826 increased interleukin-12 synthesis and inhibited interleukin-10 production
Jani et al., Plant Cell Rep 2004 : Macrophages isolated from mice immunised with native or plant expressed CTB showed enhanced secretion of interleukin-10 but secretion of lipopolysaccharide induced interleukin-12 and tumor necrosis factor alpha was inhibited
Yamaoka-Tojo et al., Heart Vessels 2003 (Acute Disease...) : Furthermore, we investigated the inhibitory effects of hr IL-10 on IL-18 production by hr CRP in human endothelial cells
Maerten et al., Clin Exp Immunol 2004 (Chronic Disease...) : In the presence of IL-18 , these T cells produced more interferon (IFN)-gamma and less IL-10
Dai et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : IL-18 dose-dependently enhanced the production of IL-1beta and TNFalpha, but not IL-10 , by monocytes following contact with RA synovial T cells or PHA prestimulated T cells
Weir et al., Infect Immun 2004 (Tuberculosis) : Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom ... To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives ( PPDs )
Zhou et al., Mol Cell Biol 2004 : Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway
Hauber et al., J Cyst Fibros 2004 (Cystic Fibrosis) : IL-10 may contribute to inhibit IL-18 expression in PBMC in CF
Romano et al., Clin Immunol 2005 (Acute Disease...) : The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects
Li et al., Cancer Res 2005 (Fibrosarcoma) : Concurrently, IL-18 prevented IL-12 stimulated TDLN cells from producing IL-10
Takahashi et al., Antimicrob Agents Chemother 2005 : In addition, ciprofloxacin suppressed the interleukin-18 induced production of tumor necrosis factor alpha, gamma interferon, and interleukin-12 in peripheral blood mononuclear cells by inhibiting the expression of intercellular adhesion molecule 1, B7.1, B7.2, and CD40 on monocytes, and this effect could be reversed by the addition of indomethacin or NS398
Warris et al., Med Mycol 2005 : By using specific cytokine inhibitors we were able to show that endogenous IL-1, but not IL-18 and TNFalpha was required for IFNgamma and IL-10 release upon stimulation with A. fumigatus hyphae, whereas conidia induced IFNgamma stimulation is independent of these cytokines
Obonyo et al., FEMS Immunol Med Microbiol 2006 (Helicobacter Infections) : Evidence for interleukin-1 independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori infected murine dendritic cells deficient in the interleukin-1 receptor
Mas et al., Mult Scler 2007 (Genetic Predisposition to Disease...) : OPN enhances the production of the pro-inflammatory cytokines, interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Yin et al., J Toxicol Environ Health 2007 (Listeriosis) : DEP or eDEP concentration-dependently suppressed L. monocytogenes induced secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-12 by AM and of IL-2 and interferon-gamma by lymphocytes obtained from L. monocytogenes infected rats, but augmented the AM secretion of IL-10
Buisson et al., J Infect Dis 2009 (HIV Infections) : These functional changes may be at least partly explained by reduced interleukin-12 and increased interleukin-10 secretion on stimulation with lipopolysaccharide and CD40 ligand
Puliti et al., Microbes Infect 2010 (Arthritis, Infectious...) : Amelioration of arthritis in B7-1 deficient mice was accompanied by a lower local production of IL-1 beta and IL-18 , and increase in IL-4 and IL-10 secretion
Li et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010 : Transcription of IL-1ß, IL-10 and IL-12 p40 mRNA was enhanced at 2 h after oxLDL stimulation ( P < 0.01 ), and transcription of IL-1ß, IL-10 and IL-18 increased significantly at 50 h compared to 2 h, whereas IL-12 decreased significantly at 50 h compared to 2 h ( P < 0.01 )
Shan et al., Thromb Res 2011 (Purpura, Thrombocytopenic, Idiopathic) : IL-18BPa/Fc at 10 ng/ml significantly stimulated IL-10 secretion from PBMCs in patients with ITP and healthy donors, while it decreased IFN-? release
Ding et al., ACS Appl Mater Interfaces 2011 : The inhibition of inducible nitric oxide synthase and interleukin-1 expression and the activation of interleukin-10 were increased with increasing gelatin content
Uchiyama et al., Journal of cardiothoracic surgery 2012 : Proliferation of splenocytes, interleukin (IL)-2 and interferon ( IFN ) -? production was suppressed in opera exposed mice, and production of IL-4 and IL-10 from opera exposed transplant recipients increased compared to that from splenocytes of untreated recipients
da Silva et al., Immunobiology 2013 : However, PGE2 alone stimulated the secretion of 208±89pgIL-10/ml whereas IL-18 alone did not stimulate the secretion of IL-10 , IL-12, TNF-a or INF-?
Chung et al., J Infect Dis 2013 (Leprosy, Lepromatous...) : Galectin-3 enhanced monocyte interleukin 10 production to a TLR2/1 ligand, whereas interleukin 12p40 secretion was unaffected
Thompson et al., J Neurotrauma 2013 (Spinal Cord Injuries) : The best characterized effects of IL-10 are anti-inflammatory-it downregulates pro-inflammatory species interleukin-1ß (IL-1ß), interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-a, interferon-?, matrix metalloproteinase-9, nitric oxide synthase, myeloperoxidase, and reactive oxygen species
Tilg et al., Cytokine 1995 (Neoplasms) : Induction of circulating interleukin 10 by interleukin 1 and interleukin 2, but not interleukin 6 immunotherapy
Benveniste et al., Proc Natl Acad Sci U S A 1996 (Acute Disease...) : Comparative interleukin ( IL-2 ) /interferon IFN-gamma and IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef truncated or pathogenic SICmac251 virus
Venkataraman et al., Cryobiology 1996 : X. Decrease in interleukin-12 production by frozen human peripheral blood mononuclear cells is mediated by the endogenously hypersecreted interleukin-10
Micallef et al., Cancer Res 1997 (Sarcoma, Experimental) : In conclusion, IL-18 seems to enhance the generation of NK activity early after tumor transplantation and simultaneously induces an increase and a decrease in the production of IL-10 and IL-2, respectively
Puren et al., J Clin Invest 1998 : IL-18 did not induce antiinflammatory cytokines, IL-1Ra, or IL-10 , although IL-18 induction of TNFalpha was inhibited by IL-10
Shibata et al., J Immunol 1998 : Exogenous IL-10 decreased IL-12- or IL-18 induced IFN-gamma levels in KO but not in WT NK cell cultures
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10 , transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Pai et al., Oncol Res 1998 : Differential effect of interleukin 10 on interleukin 12- and interleukin 2-mediated killer induction from blood mononuclear cells