Cipriano et al., J Clin Invest 2012
(Cell Transformation, Neoplastic...) :
Binding of FAM83B with CRAF disrupted CRAF/14-3-3 interactions and increased CRAF membrane localization, resulting in elevated MAPK and mammalian target of rapamycin (mTOR) signaling
Cipriano et al., Oncotarget 2013
(Cell Transformation, Neoplastic...) :
FAM83B mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies